Regulation of human adenylate cyclase

Details Regulation of human adenylate cyclase Regulation of human adenylate cyclase

2007-04-17

2007-04-17

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

C435S194000, C435S196000, C435S193000, C424S094500

Reexamination Certificate

active

10416577

ABSTRACT:
Reagents which regulate human adenylate cyclase and reagents which bind to human adenylate cyclase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, peripheral and central nervous system disorders, disorders of the genito-urinary system including but not limited to benign prostatic hyperplasia and urinary incontinence, obesity, COPD and diabetes.

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Database EMBL 'Online! ADCY2 or KIAA1060; adenylate cyclase type II, Oct. 1, 1994; Database Accession No. Q08462.
Ohara et al.: “direct submission”; Database EMBL 'Online! Homo sapiens mRNA for KIAA1060 protein, Aug. 4, 1999; Database Accession No. AB028983.
Hellevuo et al.: “A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line”; Biochem & Biophys Research Communications; vol. 192; 311-318; (1993).
Hellevuo et al.: “The characterization of a Novel Human Adenylyl Cyclase Which is Present in Brain and Other Tissues”; The Jour of Biological Chem; vol. 270; 11581-11589; May 12, 1995.
Simonds et al.: “G protein regulation of adenylate cyclase”; Trends in Pharmacological Sciences; vol. 20;66-73; Feb. 1999.

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