Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-05-27
2011-10-11
Pak, Michael (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
Reexamination Certificate
active
08034556
ABSTRACT:
The invention is based on the discovery that the gylcosylation enzyme GnT-4 increases glyocsylation and the stability of glucose transporter (Glut) family members, e.g., by increasing lectin binding. Modulators of GnT-4 activity can therefore be identified and used for the treatment of diabetes or pre-diabetes. In addition, inhibitors of GnT-4 activity can be used for the treatment of cancer.
REFERENCES:
patent: 5968764 (1999-10-01), Knowles et al.
Van Tilburg et al. (2003) J. Clin. Endo. Metab. 88: 2223-2230.
Asano et al.; “The role of N-glycosylation in the targeting and stability of GLUT1 glucose transporter”;FEBS Lett.; 324(3):258-61 (Jun. 1993).
Asano et al.; “The role of N-glycosylation of GLUT1 for glucose transport”;J. Biol. Chem.; 266(36):24632-24636-61 (1991).
Gremlich et al.; “Dexamethasone induces posttranslational degradation of GLUT2 and inhibition of insulin secretion in isolated pancreatic beta cells. Comparison with the effects of fatty acids”;J. Biol. Chem.; 272(6):3216-3222 (1997).
Joos et al.; “The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members”;Mol. Membr. Biol.; 18(4):247-256; (2001).
Lowe et al.; “A genetic approach to Mammalian glycan function”;Ann. Rev. Biochem.; 72:643-691 (epub Mar. 2003).
Uldry et al.; “The SLC2 family of facilitated hexose and polyol transporters”;Pflugers Arch—Eur J Physiol; 447:480-489 (Apr. 2004).
Uldry et al.; “The SLC2 family of facilitated hexose and polyol transporters”;Pflugers Arch—Eur J Physiol; 448(2):259-260erratum(May 2004).
Yoshida et al.; “Tissue specific expression and chromosomal mapping of a human UDP-N-acetylglucosamine: alpha1,3-d-mannoside beta1, 4-N-acetylglucosaminyltransferase”;Glycobiology; 9(3):303-310 (1999).
International Search Report and Written Opinion from PCT/US05/18910, dated Mar. 16, 2009 (9 pages).
Marth Jamey
Ohtsubo Kazuaki
Kilpatrick Townsend & Stockton LLP
Pak Michael
The Regents of the University of California
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