Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Metabolism of micro-organism enhanced
Reexamination Certificate
2001-02-22
2008-12-16
Ketter, James S (Department: 1636)
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Metabolism of micro-organism enhanced
C607S050000
Reexamination Certificate
active
07465566
ABSTRACT:
Methods and devices for the regulation of gene expression by cells via the application of fields generated by specific and selective electric and electromagnetic signals so as to target diseased or injured tissue for treatment. By gene expression is meant the up regulation or down regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased tissue that include providing specific and selective electric and electromagnetic signals and exposing tissue to the fields generated by the signals so as to regulate gene expression. In particular, methods and devices are provided for the targeted treatment of bone defects, osteoarthritis, osteoporosis, cancer, and other disease states.
REFERENCES:
patent: 4430999 (1984-02-01), Brighton et al.
patent: 4442846 (1984-04-01), Brighton et al.
patent: 4467808 (1984-08-01), Brighton et al.
patent: 4487834 (1984-12-01), Brighton
patent: 4506674 (1985-03-01), Brighton et al.
patent: 4509520 (1985-04-01), Dugot
patent: 4535775 (1985-08-01), Brighton et al.
patent: 4549547 (1985-10-01), Brighton et al.
patent: 4600010 (1986-07-01), Dugot
patent: 4683873 (1987-08-01), Cadossi et al.
patent: 4998532 (1991-03-01), Griffith
patent: 5014699 (1991-05-01), Pollack et al.
patent: 5038797 (1991-08-01), Batters
patent: 5269746 (1993-12-01), Jacobson
patent: 5273033 (1993-12-01), Hoffman
patent: 5338286 (1994-08-01), Abbott et al.
patent: 5374283 (1994-12-01), Flick
patent: 5743844 (1998-04-01), Tepper et al.
patent: 5968527 (1999-10-01), Litovitz
patent: 6083149 (2000-07-01), Wascher et al.
patent: 6132362 (2000-10-01), Tepper et al.
patent: 6186940 (2001-02-01), Kirschbaum
patent: 6261221 (2001-07-01), Tepper et al.
patent: 6292699 (2001-09-01), Simon et al.
patent: 6485963 (2002-11-01), Wolf et al.
patent: 6605089 (2003-08-01), Michelson
patent: 6747004 (2004-06-01), Tabibzadeh
patent: 6919205 (2005-07-01), Brighton
patent: 6955642 (2005-10-01), Simon
patent: 7022506 (2006-04-01), Brighton et al.
patent: 7130692 (2006-10-01), Brighton et al.
patent: 7158835 (2007-01-01), Brighton et al.
patent: 7167753 (2007-01-01), Brighton et al.
patent: 7215995 (2007-05-01), Brighton et al.
patent: 2002/0038137 (2002-03-01), Stein
patent: 2002/0052634 (2002-05-01), March
patent: 2002/0125769 (2002-09-01), Riley et al.
patent: 2003/0211084 (2003-11-01), Brighton et al.
patent: 2004/0138709 (2004-07-01), Brighton
patent: 2005/0203591 (2005-09-01), Brigton
patent: 2006/0190043 (2006-08-01), Brighton et al.
patent: 2006/0235473 (2006-10-01), Brighton
patent: 2007/0299472 (2007-12-01), Brighton
patent: 0652028 (1995-05-01), None
patent: 1198580 (2006-05-01), None
patent: WO 00/02585 (2000-01-01), None
patent: 01162336 (2001-08-01), None
patent: WO 01/62336 (2001-08-01), None
patent: WO 2005/070136 (2005-08-01), None
Aaron, R.K., et al., “The conservative treatment of osteonecrosis of the femoral head,”Clin. Orthop., 1989, 249, 209-218.
Aaron, R.K., et al., “Stimulation of experimental endochondral ossification by low-energy pulsing electromagnetic fields,”J. Bone Miner. Res., Nov. 2, 1989, 4, 227-233.
Bassett,C.A.L., “Low energy pulsing electromagnetic fields modify biomedical processes,”BioEssays, 1987, 6(1), 36-42.
Bassett, C.A.L., et al., “Effects of pulsed electromagnetic fields on Steinberg ratings of femoral head osteonecrosis,”Clin. Orthop., Sep. 1989, 246, 172-185.
Bassett, C.A.L., et al., “Fundamental and practical aspects of therapeutic uses of pulsed electromagnetic fields (PEMSs),”Crit. Rev. Biomed. Eng., 1989, 17(5), 451-529.
Bassett, C.A.L., et al., “Pulsing electromagnetic field treatment in ununited fractures and failed arthrodeses,”JAMA, Feb. 5, 1982, 247(5), 623-628.
Binder, A., et al., “Pulsed electromagnetic field therapy of persistent rotator cuff tendonitis,”Lancet, Mar. 31, 1984, 695-698.
Brighton, C.T., et al., “A multicenter study of the treatment of non-union with constant direct current,”J. Bone and Joint Surgery, Jan. 1981, 62-A(1), 2-13.
Brighton, C.T., et al., “Treatment of recalcitrant non-union with a capacitively coupled electrical field,”J. Bone and Joint Surgery, Apr. 1985, 67-A(4), 577-585.
Brighton, C.T., et al., “Treatment of castration-induced osteoporosis by a capacitively coupled electrical signal in rat vertebrae,”J. Bone and Joint Surgery, Feb. 1989, 71-A(2), 228-236.
Brighton, C.T., et al., “Increased cAMP production after short-term capacitively coupled stimulation in bovine growth plate chondrocytes,”J. Orthop. Res., 1988, 6, 552-558.
Brighton, C.T., et al., “Treatment of denervation/disuse osteoporosis in the rat with a capacitively coupled electrical signal: effects on bone formation and bone resorption,”J. Orthop. Res., 1988, 6, 676-684.
Goodman, R., et al., “Exposure of salivary gland cells to low-frequency electromagnetic fields alters polypeptide synthesis,”Proc. Natl. Acad. Sci. USA, Jun. 1988, 85, 3928-3932.
Goodwin, C.B., et al., “A double-blind study of capacitively coupled electrical stimulation as an adjunct to lumbar spinal fusions,”Spine, 1999, 24(13), 1349-1356.
Grodzinsky, A.J., “Electromechanical and physicochemical properties of connective tissue,”Crit. Rev. Biomed. Engng., 1983, 9(2), 133-198.
Harrison, M.H.M., et al., “Use of pulsed electromagnetic fields in perthes disease: report of a pilot study,”J. Pediatr. Orthop., 1984, 4, 579-584.
Jones, D.B., et al., “PEMF effects on differentiation and division in mirine melanoma cells are mediated indirectly through cAMP,”Trans. BRAGS 6, 1986, 51.
Lorich, D.G., et al., “Biochemical pathway mediating the response of bone cells to capacitive coupling,”Clin. Orthop. and Related Res., 1998, 350, 246-256.
Massardo, L., et al., “Osteoarthritis of the knee joint: an eight year prospective study,”Ann Rheum Dis., 1989, 48, 893-897.
Mooney, V., “A randomized double-blind prospective study of the efficacy of pulsed electromagnetic fields for inter body lumbar fusions,”Spine, 1990, 15(7), 708-712.
Norton, L.A., et al., “Pulsed electromagnetic fields alter phenotypic expression in chondroblasts in tissue culture,”J. Orthop. Res., 1988, 6, 685-689.
Rodan, G.A., et al., “DNA synthesis in cartilage cells is stimulated by oscillating electric fields,”Science, Feb. 10, 1978, 199, 690-692.
Ryaby, J.T., et al., “Pulsing electromagnetic fields affect the phosphorylation and expression of oncogene proteins,”Trans. BRAGS 6, 1986, p. 78.
Ryaby, J.T., et al., “The effect of electromagnetic fields on protein phosphorylation and synthesis in murine melanoma cells,”BRAGS, p. 32.
Wang, W., et al., “The increased level of PDGF-A constributes to the increased proliferation induced by mechanical stimulation in osteoblastic cells,”Biochem. And Molecular Biol. International, Oct. 1997, 43(2), 339-346.
Zhuang, H., et al., “Mechanical strain-induced proliferation of osteoblastic cells parallels increased TGF-β1 mRNA,”Biochem. Biophys. Res. Commum., 1996, 229, 449-453.
Zhuang, H., et al., “Electrical stimulation induces the level of TGF-β1 mRNA in osteoblastic cells by a mechanism involving calcium/calmodulin pathway,”Biochem. Biophys. Res. Commun., 1997, 237, 225-229.
Brighton, C.T., et al., “Fracture healing in the rabbit fibula when subjected to various capacitively coupled electrical fields,”J. Orthop. Res., 1985, 3, 331-340.
Brighton, C.T., et al., “In vitro bone-cell response to a capacitively coupled electrical field,”Clin. Orthop. Related Res., Dec. 1992, 285, 255-262.
Carter, E.L., et al., “Field distributions in vertebral bodies of the rat during electrical stimulation: a parametric study,”IEEE Tr
Brighton Carl T.
Pollack Solomon R.
Ketter James S
The Trustees of the University of Pennsylvania
Woodcock & Washburn LLP
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