Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2006-05-23
2006-05-23
Woitach, Joseph (Department: 1635)
Chemistry: molecular biology and microbiology
Vector, per se
C435S325000, C435S455000, C435S456000, C435S069100, C435S243000, C435S358000, C435S371000, C435S372000, C536S023100, C536S023400
Reexamination Certificate
active
07049133
ABSTRACT:
A cis-acting nucleotide sequence which is capable of rendering the removal of introns from a precursor transcript encoded by a gene, which gene harbors at least one such cis-acting nucleotide sequence, occurring during the production of mRNA of a gene, dependent upon activation of a trans-acting factor. The trans-acting factor is an RNA-activated protein kinase which is capable of phosphorylating the α-subunit of eukaryotic initiation factor 2. The trans-acting factor is preferably, the RNA-activated protein kinase (PKR). The cis-acting nucleotide sequence can be derived from the 3′ untranslated region of the human tumor necrosis factor α gene (TNF-α3′-UTR) and may comprise the nucleotide sequence as denoted by SEQ ID NO:1 or biologically functional fragments, derivatives, mutants and homologues thereof.
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Ben-Asouli Yitzhak
Jarrous Nayef
Kaempfer Raymond
Osman Farhat
Baker & Botts LLP
Whiteman Brian
Woitach Joseph
Yissum Research Development Company of the Hebrew University of
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