Regulation of gene expression by protein methylation

Details Regulation of gene expression by protein methylation Regulation of gene expression by protein methylation

2007-05-08

2007-05-08

Prouty, Rebecca (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

C435S193000, C530S402000

Reexamination Certificate

active

10830591

ABSTRACT:
The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.

REFERENCES:
patent: 6060250 (2000-05-01), Lal et al.
GenBank Accession No. AA 396116, Apr. 25, 1997.
GenBank Accession No. AA215095, Feb. 3, 1997.
Chen et al. “Regulations of Transcription by a Protein Methyltransferase”Science(1999) 284:2174-2177.
Han et al. “Multiple Signal Input and Output Domains of the 160-Kilodalton Nuclear Receptor Caoctivator Proteins”Molecular and Cellular Biology(1999) 19:6164-6173.

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