Regulation of gene expression

Details Regulation of gene expression Regulation of gene expression

1993-12-01

1996-09-10

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351721, 4351723, 4352401, 4352523, 4352542, 43525421, 4353201, 536 231, 536 241, 935 33, C12N 1509, C12N 1567

Patent

active

055545106

ABSTRACT:
The present invention relates to the regulation of gene expression which entails providing a pair of unlike proteins, with unlike DNA binding domains, which will associate to form a heterodimer and bind to appropriate asymmetric DNA binding sites and hence depress or increase expression of adjacent genes.

REFERENCES:
Hu and Davidson, Cell (1987) 48:555-566.
Brown et al., Cell (1987) 49:603-612.
Hu and Davidson, Gene (1988) 62:301-313.
Hollis et al., Proc. Natl. Acad. Sci. (1988) 85:5834-5838.
Koudelka et al., Nature (1987) 326:886-888.
Turner and Tjian, Science (1989) 243:1689-1694.
Wharton and Ptashne, Nature (1985) 316:601-605.
Wharton and Ptashne, Nature (1987) 326:888-891.
Lin et al., Cell (1988) 54:659-664.
Brent and Ptashne, Cell (1985) 43:729-736.
Brent and Ptashne, Nature (1984) 312:612-615.
Smith et al., EMBO J. (1988) 7:3975-3982.
Miller et al., "Identification and comparison of two sequence elements that confer cell-type specific transcription in yeast," (Apr. 18, 1985) Nature, 314:598-603.
Bender et al, "MAT.alpha.1 Protein, a yeast transcription activator, binds synergistically with a second protein to a set of cell-type-specific genes," (Aug. 28, 1987) Cell, 50:681-691.
Olesen et al, "Yeast HAP2 and HAP3 activators both bind to the CYC1 upstream activation site, UAS2, in an interdependent manner," (Dec. 24, 1987) Cell, 51:953-961.
Chodosh et al, "A yeast and a human CCAAt-binding protein have heterologous subunits that are functionally interchangeable," (Apr. 8, 1988) Cell, 53:25-35.
Ptashne et al. A Genetic Switch: Gene Control & Phage .lambda.. pp. 98-99. 1987. Cell Press. Maniatis 1982. Molecular Cloning CSH.
Webster et al. Mol. Microbiol. (1992) 6:371-377.
Thliveris et al. Biochimie (1991) 73:449-455.

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