Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-07-19
2011-07-19
Ketter, Jim (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S173800, C607S050000
Reexamination Certificate
active
07981611
ABSTRACT:
Methods and devices are described for the regulation of Fibroblastic Growth Factor-2 mRNA and/or FGF-2 protein in bone cells and other tissues via capacitive coupling or inductive coupling of specific and selective electric and/or electromagnetic fields to the bone cells or other tissues, where the specific and selective fields are generated by application of specific and selective signals to electrodes or one or more coils or other field generating device disposed with respect to the bone cells or other tissues so as to facilitate the treatment of diseased or injured bone and other tissues. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased bone and other tissue that include generating specific and selective signals that generate electric and/or electromagnetic fields in the target tissue optimized for increase of FGF-2 protein gene expression and exposing bone and other tissue to the fields generated by specific and selective signals so as to regulate FGF-2 protein gene expression in such tissue. The resulting methods and devices are useful for the targeted treatment of osteoporosis, osteopenia, osteonecrosis, fresh bone fractures, fractures at risk, nonunion, bone defects, spine fusion, and/or other conditions in which FGF-2 protein has been implicated.
REFERENCES:
patent: 4430999 (1984-02-01), Brighton et al.
patent: 4442846 (1984-04-01), Brighton et al.
patent: 4467808 (1984-08-01), Brighton et al.
patent: 4467809 (1984-08-01), Brighton
patent: 4487834 (1984-12-01), Brighton
patent: 4506674 (1985-03-01), Brighton et al.
patent: 4509520 (1985-04-01), Dugot
patent: 4535775 (1985-08-01), Brighton et al.
patent: 4549547 (1985-10-01), Brighton et al.
patent: 4600010 (1986-07-01), Dugot
patent: 4683873 (1987-08-01), Cadossi et al.
patent: 4998532 (1991-03-01), Griffith
patent: 5014699 (1991-05-01), Pollack et al.
patent: 5038797 (1991-08-01), Batters
patent: 5269746 (1993-12-01), Jacobson
patent: 5273033 (1993-12-01), Hoffman
patent: 5338286 (1994-08-01), Abbott et al.
patent: 5374283 (1994-12-01), Flick
patent: 5743844 (1998-04-01), Tepper et al.
patent: 5968527 (1999-10-01), Litovitz
patent: 6083149 (2000-07-01), Wascher et al.
patent: 6132362 (2000-10-01), Tepper et al.
patent: 6186940 (2001-02-01), Kirschbaum
patent: 6261221 (2001-07-01), Tepper et al.
patent: 6292699 (2001-09-01), Simon et al.
patent: 6485963 (2002-11-01), Wolf et al.
patent: 6605089 (2003-08-01), Michelson
patent: 6747004 (2004-06-01), Tabibzadeh
patent: 6919205 (2005-07-01), Brighton
patent: 6955642 (2005-10-01), Simon
patent: 7022506 (2006-04-01), Brighton et al.
patent: 7130692 (2006-10-01), Brighton et al.
patent: 7158835 (2007-01-01), Brighton et al.
patent: 7167753 (2007-01-01), Brighton et al.
patent: 7215995 (2007-05-01), Brighton et al.
patent: 7374916 (2008-05-01), Brighton
patent: 7429471 (2008-09-01), Brighton
patent: 7465546 (2008-12-01), Brighton
patent: 7465566 (2008-12-01), Brighton et al.
patent: 2002/0038137 (2002-03-01), Stein
patent: 2002/0052634 (2002-05-01), March
patent: 2002/0125769 (2002-09-01), Riley et al.
patent: 2003/0211084 (2003-11-01), Brighton et al.
patent: 2004/0138709 (2004-07-01), Brighton
patent: 2005/0049640 (2005-03-01), Gurtner et al.
patent: 2005/0203591 (2005-09-01), Brighton
patent: 2006/0190043 (2006-08-01), Brighton et al.
patent: 2006/0235473 (2006-10-01), Brighton
patent: 2007/0299472 (2007-12-01), Brighton
patent: 0 652 028 (1995-05-01), None
patent: 1 198 580 (2006-05-01), None
patent: 2147895 (2000-04-01), None
patent: WO 00/02585 (2000-01-01), None
patent: WO 01/62336 (2001-08-01), None
patent: WO 2004/029210 (2004-04-01), None
patent: WO 2005/002667 (2005-01-01), None
patent: WO 2005/070136 (2005-08-01), None
patent: WO 2007/142901 (2007-12-01), None
Brighton, C.T., et al., “Signal transduction in electrically stimulated bone cells,”J. Bone Joint Surg. Am., 2001, 83-A(10), 1514-1523.
Pienkowski, D., et al., “Low-power electromagnetic stimulation of osteotomized rabbit fibuiae,”J. of Bone&Joint Surgery, 1994, 76-A(4), 489-501.
Wang, W., et al., “Up-regulation of chondrocyte matrix genes and products by electric fields,”Clin. Orthopaedics&Related Res., 2004, 427S, S163-S173.
The PCT International Search Report dated Aug. 5, 2004 (PCT/US03/31793).
Brighton, C.T., et al., “Fracture healing in the rabbit fibula when subjected to various capacitively coupled electrical fields,”J. Orthop. Res., 1985, 3, 331-340.
Brighton, C.T., et al., “In vitrobone-cell response to a capacitively coupled electrical field,”Clin. Orthop. Related Res., Dec. 1992, 285, 255-262.
Carter, E.L., et al., “Field distributions in vertebral bodies of the rat during electrical stimulation: a parametric study,”IEEE Trans. on Biomed. Eng., Mar. 1989, 36(3), 333-345.
Aaron, R.K., et al., “The conservative treatment of osteonecrosis of the femoral head,”Clin. Orthop., 1989, 249, 209-218.
Aaron, R.K., et al., “Stimulation of experimental endochondral ossification by low-energy pulsing electromagnetic fields,”J. Bone Miner. Res., Nov. 2, 1989, 4, 227-233.
Bassett,C.A.L., “Low energy pulsing electromagnetic fields modify biomedical processes,”BioEssays, 1987, 6(1) , 36-42.
Bassett, C.A.L., et al., “Effects of pulsed electromagnetic fields on Steinberg ratings of femoral head osteonecrosis,”Clin. Orthop., Sep. 1989, 246, 172-185.
Bassett, C.A.L., et al., “Fundamental and practical aspects of therapeutic uses of pulsed electromagnetic fields (PEMSs),”Crit. Rev. Biomed. Eng., 1989, 17(5), 451-529.
Bassett, C.A.L., et al., “Pulsing electromagnetic field treatment in ununited fractures and failed arthrodeses,”JAMA, Feb. 5, 1982, 247(5), 623-628.
Binder, A., et al., “Pulsed electromagnetic field therapy of persistent rotator cuff tendonitis,”Lancet, Mar. 31, 1984, 695-698.
Brighton, C.T., et al., “A multicenter study of the treatment of non-union with constant direct current,”J. Bone and Joint Surgery, Jan. 1981, 62-A(1), 2-13.
Brighton, C.T., et al., “Treatment of recalcitrant non-union with a capacitively coupled electrical field,”J. Bone and Joint Surgery, Apr. 1985, 67-A(4), 577-585.
Brighton, C.T., et al., “Treatment of castration-induced osteoporosis by a capacitively coupled electrical signal in rat vertebrae,”J. Bone and Joint Surgery, Feb. 1989, 71-A(2), 228-236.
Brighton, C.T., et al., “Increased cAMP production after short-term capacitively coupled stimulation in bovine growth plate chondrocytes,”J. Orthop. Res., 1988, 6, 552-558.
Brighton, C.T., et al., “Treatment of denervation/disuse osteoporosis in the rat with a capacitively coupled electrical signal: effects on bone formation and bone resorption,”J. Orthop. Res., 1988, 6, 676-684.
Goodman, R., et al., “Exposure of salivary gland cells to low-frequency electromagnetic fields alters polypeptide synthesis,”Proc. Natl. Acad. Sci. USA, Jun. 1988, 85, 3928-3932.
Goodwin, C.B., et al., “A double-blind study of capacitively coupled electrical stimulation as an adjunct to lumbar spinal fusions,”Spine, 1999, 24(13), 1349-1356.
Grodzinsky, A.J., “Electromechanical and physicochemical properties of connective tissue,”Crit. Rev. Biomed. Engng., 1983, 9(2), 133-198.
Harrison, M.H.M., et al., “Use of pulsed electromagnetic fields in perthes disease: report of a pilot study,”J. Pediatr. Orthop., 1984, 4, 579-584.
Jones, D.B., et al., “PEMF effects on differentiation and division in mirine melanoma cells are mediated indirectly through cAMP,”Trans. BRAGS 6, 1986, 51.
Lorich, D.G., et al., “Biochemical pathway mediating the response of bone cells to capacitive coupling,”Clin.
Ketter Jim
The Trustees of the University of Pennsylvania
Woodcock & Washburn LLP
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