Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-07-08
1999-11-02
Zitomer, Stephanie
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
4353201, 530350, 5303871, 5303881, 5303884, 530825, 536237, 536 2432, 935 6, 935 77, 935 78, C12Q 168, C07H 2104, C12N 1574, C07K 1431, C07K 1612
Patent
active
059767928
ABSTRACT:
The present invention provides a staphylococcal accessory regulatory protein sar, and the gene encoding that protein(sar). This protein relates to the recognition and control of bacterial infections, particularly infections caused by Staphylococcus aureus (S. aureus). The sar protein and gene are thus useful in preventing or treating staph infections, and in diagnostic kits and assays for detecting the presence of the sar protein and sar gene.
REFERENCES:
patent: 5587288 (1996-12-01), Cheung et al.
J. Sambrook et al. "Molecular Cloning, a Laboratory Manual" Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York 1989 pp. 17.2-17.44.
S. Wnendt et al., "Characterization of the gene encoding .alpha.-sarcin, a ribosome-inactivating protein secreted by Aspergillus giganteus," Gene (1993) 124:239-244.
L. Sarada Nandivada et al. "SAR-2: Identification of a novel plasmid-encoded .beta.-lactamase from India" FEMS Microbiology Letters (1989) 57:219-222.
K. Lawton et al., "Acquired Resistance Signal Transduction in Arabidopsis is Ethylene Independent" The Plant Cell (1994) 6:581-588.
A. Cheung et al., "Regulation of exoprotein expression in Staphylococcus aureus by a locus (sar) distinct from agr" Proc. Natl. Acad. Sci. USA (1992) 89:6462-6466.
A. Camilli et al., "Insertional Mutagenesis of Listeria monocytogenes with a Novel Tn917 Derivative That Allows Direct Cloning of DNA Flanking Transposon Insertions", Journal of Bacteriology, (1990) 172:3738-3744, No. 7.
A. Cheung et al., "Cloning and Sequence of sarA of Staphylococcus aureus, a Gene Required for the Expression of agr" Journal of Bacteriology (1994) 176:4168-4172, No. 13.
E. McConkey, "Human Genetics, The Molecular Revolution" Jones and Barlett Publications, Boston (1993) p. 33.
A. Cheung, "Diminished Virulence of a sar.sup.- lagr.sup.- Mutant of Staphylococcus aureus in the Rabbit Model of Endocarditis", The Journal of Clinical Investigation, Inc. (1994) 94:1815-1822.
Archer et al. Antimicrobial Agents and Chemotherapy 38(3):447-454, Mar. 1994.
Cheung Ambrose
Fischetti Vincent A.
Siga Pharmaceuticals, Inc.
Zitomer Stephanie
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