Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2007-12-11
2011-12-20
Aeder, Sean (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Reexamination Certificate
active
08080367
ABSTRACT:
Anti-cancer drugs are identified by screening for agents and compounds which inhibit the binding of HSP90 and IP6K2. In vitro and in vivo assays can be used. Any phenomenon associated with the binding or inhibition can be monitored, including cell death, subcellular localization, catalytic activity of IP6K2, and IP7 formation.
REFERENCES:
Morrison et al (JBC, 2001, 276(27): 24965-24970.
Chakraborty et al (PNAS, Jan. 2008, 105(4):1134-1139).
Shames et al (PNAS, Feb. 2008, 105(5): 1389-1390).
International Search Report Issued Jul. 29, 2008 for PCT/US2007/025246 (WO 2008/073382 A3).
Chakraborty Anutosh
Juluri Krishna
Koldobskiy Michael
Mustafa Asif K
Patterson Randen L
Aeder Sean
Banner & Witcoff , Ltd.
The Johns Hopkins University
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