Regulation of cell proliferation and differentiation using pepti

Details Regulation of cell proliferation and differentiation using pepti Regulation of cell proliferation and differentiation using pepti

1994-07-28

1996-06-18

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, A61K 3829, C07K 14635

Patent

active

055277721

ABSTRACT:
Disclosed are methods of inhibiting proliferation and enhancing differentiation of a mammalian cell, inducing proliferation of a mammalian cell, enhancing wound healing, and stimulating hair growth using a peptide which has 10% or greater homology to a region of human parathyroid hormone or human hypercalcemic factor.

REFERENCES:
patent: 5093233 (1992-03-01), Rosenblatt et al.
patent: 5120831 (1992-06-01), Pickart
Endocrinology, vol. 118, No. 6, issued 1986, MacDonald et al, "Parahyroid Hormone Stimulates The Proliferation . . .", pp. 2445-2449.
Biological Abstracts, vol. 81,No. 2, issued 15 jan. 1986, Partridge et al, "Inhibitory Effects of Parathyroid Hormone . . .", Abstract No. 15489.
Endocrinology, vol. 108, No. 1, issued 1981, Bringhurst et al, "Bone Collagen Synthesis in Vitro . . .", pp. 103-108.
Endocrinology, vol. 123, No. 6, issued 1988, Fukagama et al. "Human Parathyroid Hormone (PTH)-Related Protein . . .", pp. 2841-2848.
J. Clin. Invest., vol 81, issued Mar. 1988, Rodan et al, "Comparison of Postreceptor Effects . . .", pp. 924-927.
J. Clin. Invest. vol. 81, issued Mar. 1988, Yates et al, "Effects of a Synthetic Peptide . . .", pp. 932-938.
Science, vol. 231, isued 24 jan. 1986, Merendino et al, "A Parathyroid Hormone-Like Protein . . .", pp. 388-390.
PNAS USA, vol. 83, issued Oct. 1986, Doppelt et al, "Inhibition of the in vivo parathyroid hormone . . .", pp. 7557-7560.
Clinical Research, vol. 37, No. 2, issued Apr. 1989, Holick et al, "Synthetic Fragments of 8th-Related Peptide . . .", p. 529A.
J. Cell Biology, vol. 107(6part 3), issued Dec. 1988, Nolick et al, "8th Related Peptide . . .", p. 40a, abstract No. 202.

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