Regulation of cell proliferation and differentation using peptid

Details Regulation of cell proliferation and differentation using peptid Regulation of cell proliferation and differentation using peptid

1995-06-06

1998-11-24

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 514 16, A61K 3803, A61K 3816, A61K 3829

Patent

active

058406905

ABSTRACT:
Disclosed are methods of inhibiting proliferation and enhancing differentiation of a mammalian cell, inducing proliferation of a mammalian cell, enhancing wound healing, and stimulating hair growth using a peptide which has 10% or greater homology to a region of human parathyroid hormone or human hypercalcemic factor.

REFERENCES:
patent: 5093233 (1992-03-01), Rosenblatt et al.
patent: 5120831 (1992-06-01), Pickart
patent: 5527772 (1996-06-01), Holick
Endocrinology, vol. 118, No. 6, issued 1986, MacDonald et al, "Parathyroid Hormone Stimulates The Proliferation . . . ", pp. 2445-2449.
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Endocrinolgoy, vol. 108, No. 1, issued 1981, Bringhurst et al, "Bone Collagen Synthesis in Vitro . . . ", pp. 103-108.
Endocrinology, vol. 123, No. 6, issued 1988, Fukuyama et al, "Human Parathyroid Hormone (PTH)-Related Protein . . . ", pp. 2841-2848.
J. Clin. Invest., vol. 81, issued Mar. 1988, Rodan et al, "Comparison of Postreceptor Effects . . . ", pp. 924-927.
J. Clin. Invest., vol. 81, issued Mar. 1988, Yates et al, "Effects of a Synthetic Peptide . . . ", pp. 932-938.
Science, vol. 231, issued 24 Jan. 1986, Merendino et al, "A Parathyroid Hormone-Like Protein . . . ", pp. 388-390.
PNAS USA, vol. 83, issued Oct. 1986, Doppelt et al, "Inhibition of the in vivo parathyroid hormone . . . ", pp. 7557-7560.
Clinical Research, vol. 37, No. 2, issued Apr. 1989, Holick et al, "Synthetic Fragments of PTH-Related Peptide . . . ", pp. 529A.
J. Cell Biology, vol. 107 (6 part 3), issued Dec. 1988, Holick et al, "PTH Related Peptide . . . ", p. 40a, abstract No. 202.

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