Regulation of cell growth by MUC1

Details Regulation of cell growth by MUC1 Regulation of cell growth by MUC1

2003-12-11

2010-06-29

Hill, Kevin K. (Department: 1633)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S007200, C435S007720, C435S007800, C435S029000

Reexamination Certificate

active

07745109

ABSTRACT:
The invention features a method of identifying a compound that inhibits (a) the physical interaction (binding) between MUC1 and tumor progressors (e.g., β-catenin, c-Src, EGF-R, p120ctn, or PKCδ) and/or (b) phosphorylation of MUC1 by tumor progressors with kinase activity (e.g., c-Src, EGF-R, or PKCδ). The invention also includes a method of inhibiting an interaction between MUC1 and β-catenin and a method of inhibiting expression of MUC1 or a tumor progressor in a cell.

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