Regulation of aureobasidin sensitivity

Details Regulation of aureobasidin sensitivity Regulation of aureobasidin sensitivity

1995-06-29

2000-01-18

Sisson, Bradley

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 4352523, 435 914, 435 6, 536 231, 536 245, 536 2432, C12N 1500

Patent

active

060156899

ABSTRACT:
The present invention provides a protein regulating the sensitivity of fungus to an antimycotic aureobasidin, a gene coding for this protein, the use thereof, an antibody for the protein and the use thereof. The invention is useful in the diagnosis and treatment for diseases including mycoses.
The invention also provides a novel chromosome integration vector capable of imparting a novel selective marker of a drug resistance to a fungal transformant, a transformant transformed with this vector and a process for producing the same. In particular, it provides a protein capable of imparting the resistance to aureobasidin and acting as a selective marker and a DNA coding for the same.

REFERENCES:
Boyer, J. et al. (1994) Accession No. Z28004 EMBL/GenBank/DDBJ databases. S. cerevisiae Chromosome XI Reading Frame ORF YKL004w.
Boyer et al. (1994) EMBL/GenBAnk/DDBJ Database, Accession No. Z28004.
Boyer et al. (1994) EMBL/GenBank/DDBJ Database, Accession No. P36107.
Boyer et al. (1994) EMBL/GenBank/DDBJ Database, Accession No. S37815, S77108.
Haffter et al., Suppression of carboxy-terminal truncations of the yeast mitochondrial mRNA-specific translational; activator PET122 by mutations in two new genes, MRP17 and PET127, Mol. Gen. Genet. (1992) 235: pp. 64-73.
Y. Yoshikawa et al. "Isolation, Structures, and Antifungal Activities of New Aureobasidins", The Journal of Antibiotics, vol. 46, No. 9, pp. 1347-1354, Sep. 1993.
EMBL/GenBank/DDBJ databases (Oct. 5, 1994) Boyer, J. et al. "S. cerevisiae chromosome XI reading frame ORF YKL004w" XP002011025.
EMBL/GenBank/DDBJ databanks (Jan. 6, 1994) Boyer, J. et al. "Hypothetical 45.2KD protein RPL14A-MRP17 intergenic region" XP002011027.

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