Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2006-06-27
2006-06-27
Andres, Janet L. (Department: 1647)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S006120, C435S007100, C514S002600, C536S023100, C536S023500
Reexamination Certificate
active
07067317
ABSTRACT:
Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided.
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Eisenberg Stephen P.
Jamieson Andrew
Jarvis Eric
Liu Pei-Qi
Liu Qiang
Andres Janet L.
Sangamo BioSciences, Inc.
Seharaseyon Jegatheesan
Townsend and Townsend / and Crew LLP
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