Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Metabolism of micro-organism enhanced
Reexamination Certificate
2002-09-26
2008-05-20
Ketter, James (Department: 1636)
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Metabolism of micro-organism enhanced
C607S050000
Reexamination Certificate
active
07374916
ABSTRACT:
Methods and devices for the regulation of aggrecan gene expression in cartilage cells via the application of fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression is meant the up regulation or down regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased cartilage tissue that include generating specific and selective electric and electromagnetic signals that generate fields optimized for aggrecan gene expression and exposing cartilage tissue to the fields generated by specific and selective signals so as to regulate aggrecan gene expression in such cartilage tissue. The resulting methods and devices are useful for the targeted treatment of osteoarthritis, rheumatoid arthritis, cartilage injury, and cartilage defects.
REFERENCES:
patent: 4430999 (1984-02-01), Brighton et al.
patent: 4442846 (1984-04-01), Brighton et al.
patent: 4467808 (1984-08-01), Brighton et al.
patent: 4467809 (1984-08-01), Brighton
patent: 4487834 (1984-12-01), Brighton
patent: 4506674 (1985-03-01), Brighton et al.
patent: 4509520 (1985-04-01), Dugot
patent: 4535775 (1985-08-01), Brighton et al.
patent: 4549547 (1985-10-01), Brighton et al.
patent: 4600010 (1986-07-01), Dugot
patent: 4683873 (1987-08-01), Cadossi et al.
patent: 4998532 (1991-03-01), Griffith
patent: 5014699 (1991-05-01), Pollack et al.
patent: 5038797 (1991-08-01), Batters
patent: 5269746 (1993-12-01), Jacobson
patent: 5273033 (1993-12-01), Hoffman
patent: 5338286 (1994-08-01), Abbott et al.
patent: 5374283 (1994-12-01), Flick
patent: 5743844 (1998-04-01), Tepper et al.
patent: 5968527 (1999-10-01), Litovitz
patent: 6083149 (2000-07-01), Wascher et al.
patent: 6132362 (2000-10-01), Tepper et al.
patent: 6186940 (2001-02-01), Kirschbaum
patent: 6261221 (2001-07-01), Tepper et al.
patent: 6292699 (2001-09-01), Simon et al.
patent: 6485963 (2002-11-01), Wolf et al.
patent: 6605089 (2003-08-01), Michelson
patent: 6747004 (2004-06-01), Tabibzadeh
patent: 6919205 (2005-07-01), Brighton
patent: 6955642 (2005-10-01), Simon
patent: 7022506 (2006-04-01), Brighton et al.
patent: 7130692 (2006-10-01), Brighton et al.
patent: 7158835 (2007-01-01), Brighton et al.
patent: 7167753 (2007-01-01), Brighton et al.
patent: 7215995 (2007-05-01), Brighton et al.
patent: 2002/0052634 (2002-05-01), March
patent: 2002/0125769 (2002-09-01), Riley et al.
patent: 2006/0235473 (2003-10-01), Brighton
patent: 2003/0211084 (2003-11-01), Brighton et al.
patent: 2004/0138709 (2004-07-01), Brighton
patent: 2005/0203591 (2005-09-01), Brighton
patent: 2006/0190043 (2006-08-01), Brighton et al.
patent: 2007/0299472 (2007-12-01), Brighton
patent: 1198580 (2006-05-01), None
patent: WO 00/02585 (2000-01-01), None
patent: 200162336 (2001-08-01), None
patent: WO 01/62336 (2001-08-01), None
patent: WO 2005/070136 (2005-08-01), None
Aaron, R.K., et al., “The conservative treatment of osteonecrosis of the femoral head,”Clin. Orthop., 1989, 249, 209-218.
Aaron, R.K., et al., “Stimulation of experimental endochondral ossification by low-energy pulsing electromagnetic fields,”J. Bone Miner. Res., Nov. 2, 1989, 4, 227-233.
Bassett,C.A.L., “Low energy pulsing electromagnetic fields modify biomedical processes,”BioEssays, 1987, 6(1) , 36-42.
Bassett, C.A.L., et al., “Effects of pulsed electromagnetic fields on Steinberg ratings of femoral head osteonecrosis,”Clin. Orthop., Sep. 1989, 246, 172-185.
Bassett, C.A.L., et al., “Fundamental and practical aspects of therapeutic uses of pulsed electromagnetic fields (PEMSs),”Crit. Rev. Biomed. Eng., 1989, 17(5), 451-529.
Bassett, C.A.L., et al., “Pulsing electromagnetic field treatment in ununited fractures and failed arthrodeses,”JAMA, Feb. 5, 1982, 247(5), 623-628.
Binder, A., et al., “Pulsed electromagnetic field therapy of persistent rotator cuff tendonitis,”Lancet, Mar. 31, 1984, 695-698.
Brighton, C.T., et al., “A multicenter study of the treatment of non-union with constant direct current,”J. Bone and Joint Surgery, Jan. 1981, 62-A(1), 2-13.
Brighton, C.T., et al., “Treatment of recalcitrant non-union with a capacitively coupled electrical field,”J. Bone and Joint Surgery, Apr. 1985, 67-A(4), 577-585.
Brighton, C.T., et al., “Treatment of castration-induced osteoporosis by a capacitively coupled electrical signal in rat vertebrae,”J. Bone and Joint Surgery, Feb. 1989, 71-A(2), 228-236.
Brighton, C.T., et al., “Increased cAMP production after short-term capacitively coupled stimulation in bovine growth plate chondrocytes,”J. Orthop. Res., 1988, 6, 552-558.
Brighton, C.T., et al., “Treatment of denervation/disuse osteoporosis in the rat with a capacitively coupled electrical signal: effects on bone formation and bone resorption,”J. Orthop. Res., 1988, 6, 676-684.
Goodman, R., et al., “Exposure of salivary gland cells to low-frequency electromagnetic fields alters polypeptide synthesis,”Proc. Natl. Acad. Sci. USA, Jun. 1988, 85, 3928-3932.
Goodwin, C.B., et al., “A double-blind study of capacitively coupled electrical stimulation as an adjunct to lumbar spinal fusions,”Spine, 1999, 24(13), 1349-1356.
Grodzinsky, A.J., “Electromechanical and physicochemical properties of connective tissue,”Crit. Rev. Biomed. Engng., 1983, 9(2), 133-198.
Harrison, M.H.M., et al., “Use of pulsed electromagnetic fields in perthes disease: report of a pilot study,”Pediatr. Orthop., 1984, 4, 579-584.
Jones, D.B., et al., “PEMF effects on differentiation and division in mirine melanoma cells are mediated indirectly through cAMP,”Trans. BRAGS 6, 1986, 51.
Lorich, D.G., et al., “Biochemical pathway mediating the response of bone cells to capacitive coupling,”Clin. Orthop. and Related Res., 1998, 350, 246-256.
Massardo, L., et al., “Osteoarthritis of the knee joint: an eight year prospective study,”Ann Rheum Dis., 1989, 48, 893-897.
Mooney, V., “A randomized double-blind prospective study of the efficacy of pulsed electromagnetic fields for inter body lumbar fusions,”Spine, 1990, 15(7), 708-712.
Norton, L.A., et al., “Pulsed electromagnetic fields alter phenotype expression in chondroblasts in tissue culture,”J. Orthop. Res., 1988, 6, 685-689.
Rodan, G.A., et al., “DNA synthesis in cartilage cells is stimulated by oscillating electric fields,”Science, Feb. 10, 1978, 199, 690-692.
Ryaby, J.T., et al., “Pulsing electromagnetic fields affect the phosphorylation and expression of oncogene proteins,”Trans. BRAGS 6, 1986, p. 78.
Ryaby, J.T., et al., “The effect of electromagnetic fields on protein phosphorylation and synthesis in murine melanoma cells,”Trans. BRAGS 6, 1986, p. 32.
Wang, W., et al., “The increased level of PDGF-A contributes to the increased proliferation induced by mechanical stimulation in osteoblastic cells,”Biochem. Biophys. Res. Commun., Oct. 1997, 43 (2), 339-346.
Zhuang, H., et al., “Mechanical strain-induced proliferation of osteoblastic cells parallels increased TGF-β1 mRNA,”Biochem. Biophys. Res. Commum., 1996, 229, 449-453.
Zhuang, H., et al., “Electrical stimulation induces the level of TGF-β1 mRNA in osteoblastic cells by a mechanism involving calcium/calmodulin pathway,”Biochem. Biophys. Res. Commun., 1997, 237, 225-229.
Brighton, C.T., et al., “Fracture healing in the rabbit fibula when subjected to various capacitively coupled electrical fields,”J. Orthop. Res., 1985, 3, 331-340.
Brighton, C.T., et al., “ In vitro bone-cell response to a capacitively coupled electrical field,”Clin. Orthop. Related Res., Dec. 1992, 285, 255-262.
Carter, E.L., et al.,
Ketter James
The Trustees Of The University of Pennsylvania
Woodcock & Washburn LLP
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