Regulating neuropeptide hormone secretion

Details Regulating neuropeptide hormone secretion Regulating neuropeptide hormone secretion

1995-04-03

1996-08-27

Naff, David M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514177, 514178, 514170, A01N 4500, A61K 3156

Patent

active

055501206

ABSTRACT:
Methods are described for regulating neuropeptide secretion to alleviate premature labor, hypertension, fluid imbalance, and risk of heart disease: using neuroactive steroids targeted for a newly-identified site of action in the nerve terminals of neurosecretory neurons. The steroids 17 betaestradiol and dehydroepiandrosterone increase the release of neuropeptide hormones such as oxytocin and vasopressin. Pregnalone derivatives decrease the release of the same hormones.

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