Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2011-06-21
2011-06-21
Whiteman, Brian (Department: 1635)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C424S184100, C514S002600
Reexamination Certificate
active
07964573
ABSTRACT:
The present invention relates to compositions related to a polynucleotide encoding a transient receptor potential channel gene. Also disclosed is the use of this polynucleotide, its homologs, fragments, variants and its resultant polypeptides in the diagnosis, prevention and treatment of disease, particularly idiopathic pulmonary arterial hypertension (IPAH). This invention also teaches the use of these polynucleotides and polypeptides as assays for drug discovery and therapies.
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Yu et al. (AJP Cell Physiol 284: C316-C330, 2003).
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Holen et al. (2002) Nucleic Acids Res. 30:1757-1766.
Boese et al., “Mechanical Insights Aid Computational Short Interfering RNA Design,” Methods in Enzymology 392:73-96, 2005.
Reynolds et al., “Rational siRNA design for RNA interference,” Nature Biotechnology 22:326-330, 2004.
Yu, Ying et al., “Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension,” Proceedings of the National Academy of Sciences of the United States of America (2004), 101(38), 13861-13866.
Remillard Carmelle
Rubin Lewis J.
Yu Ying
Yuan Jason X.-J.
RatnerPrestia
The Regents of the University of California
Whiteman Brian
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