Regulated nucleic acid expression system

Details Regulated nucleic acid expression system Regulated nucleic acid expression system

2004-12-13

2011-10-25

Lucas, Zachariah (Department: 1648)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S093210, C435S320100

Reexamination Certificate

active

08043611

ABSTRACT:
The present invention provides nucleic acid constructs, expression systems, and methods relating to the regulation of gene expression. The invention may be applied to regulate the expression of any coding sequence of interest, including those coding for viral components necessary for the packaging of viral particles.

REFERENCES:
patent: WO-99/41397 (1999-08-01), None
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Yu et al., Inducible Human Immunodeficiency Virus Type 1 Packaging Cell Lines, Journal of Virology, 1996, 70(7):4530-4537.
Dropulic et al., PNAS USA (1996) 93:11103-11108.
Mautino et al., Human Gene Therapy (2000) 11(14):2025-2037.
Mautino et al., Gene Therapy (2000) 7(16):1421-1424.
Mautino et al., Human Gene Therapy (2000) 11(6):895-908.
“Autologous T Cells Transduced With VRX496, An HIV-1 Based Lentiviral Vector for the Treatment of Patient-Subjects Infected With HIV-1” FDA Biological Response Modifiers Advisory Committee Meeting Briefing Package, submitted by VIRxSYS Corporation on Oct. 26, 2001.
Office Action for Russian Application No. 2004116319/13(017789), date mailed on Feb. 27, 2007, 6 pages.
Prasolov and Ivanov, Retroviral Vectors in Gene Therapy, Vopr Med Khim (2000) 46(3):207-225 (English abstract included), Only English abstract considered.
Prasolov et al., Retroviral Vectors in Gene Therapy, Questions Med. Chem. (2000) 3:1-18 (with English translation of pp. 11-13).

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