Regulated apoptosis

Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4353201, 435325, 435366, 536234, C12N 1562, C12N 1563, C12N 1579, C12N 510

Patent

active

058342664

ABSTRACT:
We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials for using that procedure to regulatably initiate cell-specific apoptosis (programmed cell death) in genetically engineered cells.

REFERENCES:
patent: 5171671 (1992-12-01), Evans et al.
Schreiber, "Chemistry and Biology of the Immunophilins and Their Immuno-suppressive Ligands", Science, 251:283-287 (1991).
Palmiter et al., "Transgenic Mice", Cell 41:343-345 (1985).
Itoh et al., "Effect of bcl-2 on Fas Antigen-Mediated Cell Death", Journal of Immunology 151:621-627 (1993).
Itoh and Nagata, "A Novel Protein Domain Required for Apoptosis", JBC 268:10932-10937 (1993).
Ptashne et al., "Activators and Targets", Nature 346:329-331 (1990).
Irving and Weiss, "The Cytoplasmic Domain of the T Cell Receptor .zeta. Chain is Sufficient to Couple to Receptor-Associated Signal Transduction Pathways"; Cell 64:891-901 (1991).
Kinet, "Antibody-Cell Interactions: Fc Receptors"; Cell 57:351-354 (1989).
Orloff et al., "Family of Disulphide-Linked Dimers Containing the .zeta. and .eta. Chains of the T-Cell Receptor and the .gamma. Chain of Fc Receptors"; Nature 347:189-191 (1990).
Durannd et al., "Characterization of Antigen Receptor Response Elements Within the Interleukin-2 Enhancer"; Mol. Cell Biol. 8(2):1715-1724 (1988).
Letourneur and Klausner, Activation of T Cells by a Tyrosine Kinase Activation Domain in the Cytoplasmic Tail of CD3 .epsilon.; Science 255:79-82 (1992).
Flanagan et al., "Nuclear Association of a T-Cell Transcription Factor Blocked by FK-506 and Cyclosporin A"; Nature 352:803-807 (1991).
Byrn et al., "Biological Properties of a CD4 Immunoadhesion"; Nature 344:667-670 (1990).
Lanier et al., "Co-association of CD3.zeta. with a Receptor (CD16) for IgG Fc on Human Natural Killer Cells"; Nature 342:803-805.
Mattila et al., "The Actions of Cyclosporin A and FK506 Suggest a Novel Step in the Activation of T Lymphocytes"; EMBO J. 9(13):4425-4433.
Verweij et al., "Cell Type Specificity and Activation Requirements for NFAT-1 (Nuclear Factor of Activated T-Cells) Transcriptional Activity Determined by a New Method Using Transgenic Mice to Assay Transcriptional Activity of an Individual Nuclear Factor"; J. Biol. Chem. 265(26):15788-15795 (1990).
Clark et al., "The B Cell Antigen Receptor Complex: Association of Ig-.alpha. and Ig-.beta. with Distinct Cytoplasmic Effectors"; Science 258:123-126 (1992).
Shaw et al., "Identification of a Putative Regulator of Early T Cell Activation Genes", Science 241:202-205 (1988).
Weissman et al., "Molecular Cloning and Chromosomal Localization of the Human T-Cell Receptor .zeta. Chain: Distinction from the Molecular CD3 Complex"; Proc. Natl. Acad. Sci. USA 85:9709-9713 (1988).
Emmel et al., "Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T-Cell Activation"; Science 246:1617-1620 (1989).
Eberle and Nuninger, "Synthesis of the Main Metabolite (OL-17) of Cyclosporin A"; J. Org. Chem. 57:2689-2691 (1992).
Traber et al., "Cyclosporins--New Analogues by Precursor Directed Biosynthesis"; J. Antibiotics 42:591-597 (1989).
Patchett et al., "Analogs of Cyclosporin A Modified at the D-ALA.sup.8 Position"; J. Antibiotics 45:94-102 (1992).
Donald et al., "C10 N-Acyl Modified FK-506: A Possible Hybrid Analogue of the Transition State of Peptidyl-Prolyl Cis-Trans Isomerization"; Tetrahedron Letters 31:1375-1378 (1991).
Nussbaumer et al., C9-Imino and C10-Amino Derivatives of Ascomycin (21-Ethyl-FK506); Tetrahedron Letters 33:3845-3846 (1992).
Evans et al., "Rhodium(I)- and Iridium(I)-Catalyzed Hydroboration Reactions: Scope and Synthetic Applications"; J. Am. Chem. Soc. 114:6671-6679 (1992).
Evans et al., "Mechanistic Study of the Rhodium(I)-Catalyzed Hydroboration Reaction"; J. Am. Chem. Soc. 114:6679-6685 (1992).
Ghosh et al., "N,N'-Disuccinimidyl Carbonate: A Useful Reagent for Alkoxycarbonylation of Amines"; Tetrahedron Letters 33:2781-2784 (1992).
Zelle et al., "A Systematic Degradation of Zincophorin: A Stereoselective Synthesis of the C.sub.17 -C.sub.25 Fragment"; J. Org. Chem. 51:5032-5036 (1986). Remarkably Chemoselective Reagent for the Reduction of Aldehydes in the Presence of Ketones"; J. Org. Chem. 46:4628-4629 (1981).
Fisher et al., "On the Remarkable Propensity for Carbon-Carbon Bond Cleavage Reactions in the C.sub.8 -C.sub.10 Region of FK-506"; J. Org. Chem. 56:2900-2907 (1991).
VanRheenen et al., "An Improved Catalytic OsO.sub.4 Oxidation of Olefins to Cis-1,2-Glycols Using Tertiary Amine Oxides as the Oxidant"; Tetrahedron Letters 23:1973-1976 (1976).
Fields, S. and Song, O., "A novel genetic system to detect protein-protein interactions"; Nature 340:245-246 (1989).
W. James, "Towards gene-inhibition therapy: a review of progress and prospects in the field of antiviral antisense nucleic acids and ribozymes" Antiviral Chemistry and Chemotherapy, vol. 2, No. 4, (1991) pp. 191-214.
Watanabe-Fukunaga et al., "Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis" Nature, vol. 356, pp. 314-317 (1992).
Lee et al., "HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor" EMBO Journal vol. 8, pp. 167-173 (1989).
Moe et al., "Transmembrane signaling by a chimera of the Escherichia coli aspartate receptor and the human insulin receptor" Proceedings of the National Academy of Sciences of USA, vol. 86, pp. 5683-5687 (1989).
Sistonen et al., "Activation of the new tryosine kinase . . . " J. Cell Biology, vol. 109, pp. 1911-1919 (1989).
Peles et al., "Regulated coupling of the Neu receptor to phosphatidylinositol . . . " J. Biological Chemistry, vol. 267, pp. 12266-12274 (1992).
Wittbrodt et al., "The Xmrk receptor tyrosine kinase is activated in Xiphophorous malignant melanoma" EMBO Journal, vol. 11, pp. 4239-4246 (1992).
Bernard et al., "High-affinity interleukin 2 binding by an oncogenic hybrid interleukin 2-epidermal growth factor receptor molecule" Proceedings of the National Academy of Sciences USA, vol. 84, pp. 2125-2129 (1987).
Lammers et al., "Differential signalling potential in insulin- and IGF-1-receptor cytoplasmic domains" EMBO Journal, vol. 8, pp. 1369-1375 (1989).
Lehtola et al., "Receptor downregulation and DNA synthesis are modulated by EGF and TPA in cells expressing an EGFR
eu chimera" Growth Factors, vol. 1, pp. 323-334 (1989).
Lehvaslaiho et al., "A chimeric EGF-R-neu proto-oncogene allows EGF to regulate neu tyrosine kinase and cell transformation" EMBO Journal, vol. 8, pp. 159-166 (1989).
Margolis et al., "All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2
eu are located in their carboxyl-terminal tails" Journal of Biological Chemistry, vol. 264, pp. 10667-10671 (1989).
Riedel et al, "Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors" EMBO Journal, vol. 8, pp. 2943-2954 (1989).
Roussel et al., "Antibody-induced mitogenicity mediated by a chimeric CD2-c-fms receptor" Molecular and Cellular Biology, vol. 10, pp. 2407-2412 (1990).
Chan et al., "The .zeta. chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein" Proceedings of the National Academy of Sciences USA, vol. 88, pp. 9166-9170 (1991).
Herbst et al., "Substrate phosphorylation specificity of the human c-kit receptor tyrosine kinase" J. Biological Chemistry, vol. 266, No. 30, pp. 19908-19916 (1991).
Lev et al., "A specific combination of substrates is involved in signal transduction by the kit-encoded receptor" EMBO Journal, vol. 10, pp. 647-654 (1991).
Yan et al., "Chimeric NGF-EGF receptors define domains responsible for neuronal differentiation" Science, vol. 252, pp. 561-563 (1991).
Ben-Levy et al., "An oncogenic point mutation confers high affinity ligand binding to the neu receptor" J. Biological Chemistry, vol. 267, pp. 17304-17313 (1992).
Bonnerot et al., "Role of associated .gam

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Regulated apoptosis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Regulated apoptosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Regulated apoptosis will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1515630

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.