Regulatable RNA molecule

Details Regulatable RNA molecule Regulatable RNA molecule

1995-06-02

1998-11-10

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435 9131, 4351721, 4351723, 536 231, 536 232, 536 245, C12Q 168, C12N 1509

Patent

active

058341862

ABSTRACT:
Regulatable RNA molecules such as regulatable ribozymes, nucleic acids encoding such regulatable ribozymes, and methods of making and using such regulatable ribozymes are disclosed. Regulatable ribozymes comprise a ligand-binding RNA sequence and a ribozyme sequence capable of cleaving a separate targeted RNA sequence, wherein upon binding of the ligand to the ligand-binding RNA sequence, the activity of the ribozyme sequence against the targeted RNA sequence is altered. The ligand may be either an inorganic or an organic molecule and may be a co-drug which can be administered to specifically regulate the ribozyme activity. Regulatable RNA molecules other than ribozymes are also disclosed, such as regulatable mRNA molecules which comprise a ligand-binding RNA sequence separate from the coding sequence, wherein upon binding of a ligand to the ligand-binding RNA sequence, translation of the regulatable mRNA is altered.

REFERENCES:
Robertson et al. Nature 344:467-468 (1990).
Stull et al. Pharm. Res. 12:465-483 (1995).

Affiliated with

Also associated with

Rating

Regulatable RNA molecule does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Regulatable RNA molecule, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Regulatable RNA molecule will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1515194