Regulatable retrovirus system for genetic modification of cells

Details Regulatable retrovirus system for genetic modification of cells Regulatable retrovirus system for genetic modification of cells

1996-02-20

1998-06-23

Ketter, James

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4353201, 435353, 435357, C12N 1500

Patent

active

057704147

ABSTRACT:
A novel regulatable retroviral vector in which the v-myc oncogene is driven by a tetracycline-controlled transactivator and a human cytomegalovirus minimal promoter fused to tet operator sequence useful for immortalization of adult neuronal progenitor cells is provided. Regulation of a heterologous Producer cell lines which produce high titers of the recombinant retrovirus are also provided.

REFERENCES:
patent: 5464758 (1995-11-01), Gossen et al.
patent: 5514552 (1996-05-01), Rosner et al.
Strair et al., "Retroviral mediated transfer and expression of exogenous genes in primary lymphoid cells: Assaying for a viral transactivator activity in normal and malignant cells", Blood 76(6): 1201-1208, Sep. 15, 1990.
Ryder, et al., Establishment and Characterization of Multipotent Neural Cell Lines Using Retrovirus Vector-Mediated Oncogene Transfer, Journal of Neurobiology, 21:356, 1990.
Bartlett, et al., Immortalization of Mouse Neural Precursor Cells by the c-myc Oncogene, Proc. Natl. Acad. Acad. Sci. USA, 85:3255, 1988.
Gossen, et al., Transcriptional Activation by Tetracyclines in Mammalian Cells, Science, 268:1766, 1995.
Snyder, et al., Multipotent Neural Cell Lines can Engraft and Participate in Development of Mouse Cerebellum, Cell, 66:33, 1992.

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