Regiospecific synthesis of rapamycin 42-ester derivatives

Details Regiospecific synthesis of rapamycin 42-ester derivatives Regiospecific synthesis of rapamycin 42-ester derivatives

2007-09-11

2007-09-11

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C540S456000

Reexamination Certificate

active

11103799

ABSTRACT:
A method for the regiospecific synthesis of rapamycin 42-ester derivatives is described. The method involves lipase-catalyzed acetylation of 42-hydroxy of rapamycin with an acyl donor such as a vinyl ester, an isopropenyl ester or an anhydride in a suitable organic solvent.

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