Regiospecific synthesis of nicotine derivatives

Details Regiospecific synthesis of nicotine derivatives Regiospecific synthesis of nicotine derivatives

2006-09-26

2006-09-26

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S280100, C546S014000

Reexamination Certificate

active

07112678

ABSTRACT:
Methods of synthesizing nicotine analogs and derivatives are described. The methods are particularly useful for the regioselective production of enantiomerically pure nicotine anlogs having substituents at the C4 position. Intermediates useful for the synthesis of such compounds are also described.

REFERENCES:
patent: 4855433 (1989-08-01), Zeldin
patent: 5594011 (1997-01-01), McDonald et al.
patent: 5723477 (1998-03-01), McDonald et al.
U.S. Appl. No. 10/925,516, filed Aug. 2004, Commins, et al.
Bleicher et al.,A Practical and Efficient Synthesis of the Selective Neuronal Acetylcholine-Gated Ion Channel Agonist(S)-(-)-5-Ethynyl-3-)1-methyl-2-pyrrolidinyl)pyridine Maleate, J. Org. Chem., 63:1109-1118 (1998).
Brown et al.,A Convenient Synthesis of Dimethyl(Diazomethyl)phosphonate(Seyferth/Gilgert Reagent),J. Org. Chem., 61:2540-2541 (1996).
Despagnet et al.,Synthesis of Nicotine Derivatives from Nicotine, ACS Southeast Regional Meeting Abstract, Aug. 27, 2003.
Gros et al.,Lithiation of 2-Heterosubstituted Pyridines with BuLi-LiDMAE: Evidence for Regiospecificity at C-6, J. Org. Chem., 67:234-237 (2002).
Notification of Transmittal of the International Search Report for international application PCT/US03/37655. Mailed May 12, 2004.

Affiliated with

Also associated with

Rating

Regiospecific synthesis of nicotine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Regiospecific synthesis of nicotine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Regiospecific synthesis of nicotine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3538802