Regiospecific process for synthesis of acyclic nucleosides

Details Regiospecific process for synthesis of acyclic nucleosides Regiospecific process for synthesis of acyclic nucleosides

1997-06-12

2000-03-28

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

C07D47318

Patent

active

060433647

ABSTRACT:
N-7 isomer of the formula ##STR1## is converted into a N-9 isomer of the formula ##STR2## by heating a suspension of the N-7 isomer in an alkylating agent of the formula ##STR3##

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Boryski, Nucleoside and Nucleotides 8, 529, 1989.
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Martin, J. Med Mart. Chem. 29, 1384 (1986).
Translation of JP 63-107982 (1988).
Dudycz, L. W. et al., "A Simple One-Pot Method for 6-Oxopurine Ribonucleoside Synthesis: Control and Mechanism of Isomer Distribution," Nucleosides and Nucleotides, 3(1):33-44 (1984).
Wright, G.E. et al., "Synthesis and Characterization of N.sup.2 -(p-n-Butylphenyl)-2'-deoxyguanosine and Its 5'-Triphosphate and Their Inhibition of HeLa DNA Polymerase .alpha.," Journal of Medicinal Chemistry, 27(2):175-181 (1984).

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