Regioselective synthesis of CCI-779

Details Regioselective synthesis of CCI-779 Regioselective synthesis of CCI-779

2006-12-26

2006-12-26

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C549S213000

Reexamination Certificate

active

07153957

ABSTRACT:
A method for regioselective synthesis of CCl-779 based on boronate chemistry is provided. Also provided are novel intermediates useful in this method.

REFERENCES:
patent: 5362718 (1994-11-01), Skotnicki et al.
patent: 6197967 (2001-03-01), Vollmueller et al.
patent: 6277983 (2001-08-01), Shaw et al.
patent: WO 95/28406 (1995-10-01), None
Steffan et al, Base Catalyzed Degradations of Rapamycin, Tetrahedron Letters, vol. 34, No. 23, pp. 3699-2702, (1993).
Skotnicki et al, Synthesis of Secorapamycin Esters and Amides1, Tetrahedron Letters, vol. 35, No. 2, pp. 197-200, (1994).
Sehgal, Sirolimus: A New Immunosuppressive Agent, Chapter 12.1, Principles of Drug Development in Transplantation and Autoimmunity, pp. 271-282, (1996).
Caufield et al, Structure-Activity Involving Modifications to the Macrolides FK-506 and Rapamycin, Current Pharmaceutical Design, vol. 1, No. 2, pp. 145-160, (1995).
Sehgal et al, Rapamycin: A Novel Immunosuppressive Macrolide, Medicinal Research Reviews, vol. 14, No. 1, pp. 1-22, (Jan. 1994).
Hughes et al, The Isolation, Synthesis and Characterization of An Isomeric Form of Rapamycin, Tetrahedron Letters, vol. 33, No. 33, pp. 4739-4742, (1992).
H. Piotrowska, et al., Heterocyclic Derivatives of Ethyl Nitroacetate, Bulletin De L'Academie Polonaise Des Sciences, May 26, 1971, pp. 591-594, vol 19, No. 10, XP009043676.

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