Regioselective synthesis of 1,5-diaryl pyrazole anti-inflammator

Details Regioselective synthesis of 1,5-diaryl pyrazole anti-inflammator Regioselective synthesis of 1,5-diaryl pyrazole anti-inflammator

1993-08-27

1995-01-10

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23112

Patent

active

053808690

ABSTRACT:
The invention provides a process for preparing 1,5-diaryl pyrazole anti-inflammatory agents. A 6-aryl-4,6-dioxohexanoic acid is treated with acetic anhydride or acetyl chloride to produce an enol lactone, which is added to methylhydroxylamine to generate the dione hydroxamic acid. This dione hydroxamic acid is then treated with 4-methoxyphenylhydrazine hydrochloride to yield the 1,5-diaryl pyrazole. Novel intermediate compounds in the synthetic pathway are also disclosed.

REFERENCES:
patent: 4826868 (1989-05-01), Watcher et al.
patent: 4898952 (1990-02-01), Murray et al.

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