Regioselective substitutions in cyclodextrins

Details Regioselective substitutions in cyclodextrins Regioselective substitutions in cyclodextrins

1990-12-17

1992-03-17

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536103, 514936, A61K 31715, C08B 3716

Patent

active

050968939

ABSTRACT:
A method for obtaining a desired pattern of substitution of hydroxyalkyl groups on cyclodextrins which comprises controlling the basicity of a reaction mixture comprising epoxide and cyclodextrins and a suitable solvent. Through the proper control of basicity with, e.g., sodium hydroxide, hydroxyalkyl substitution may be directed either toward the narrow or wide opening of the cavity of cyclodextrins.

REFERENCES:
patent: 3459731 (1969-08-01), Gramera et al.
patent: 4582900 (1986-04-01), Brandt et al.
patent: 4596795 (1986-06-01), Pitha
patent: 4638058 (1987-01-01), Brandt
patent: 4727064 (1988-02-01), Pitha
patent: 4764604 (1988-08-01), Muller
patent: 4877778 (1989-10-01), Carpenter et al.

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