Regioselective liquid phase pegylation

Details Regioselective liquid phase pegylation Regioselective liquid phase pegylation

2007-08-14

2007-08-14

Tsang, Cecilia J. (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

Reexamination Certificate

active

10398397

ABSTRACT:
A method is described for a method for the regioselective liquid-phase pegylation of GRF, which increases the yield of the GRF-PEG conjugate having 1 PEG molecule covalently bound to the e-amino group of Lys12. This method is characterized in that the reaction is carried out in a structuring solvent, such as trifluorethanol.

REFERENCES:
patent: WO99/27897 (1999-06-01), None
patent: WO99/27897 (1999-08-01), None
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