Regioselective chemical modification of monoclonal antibodies

Details Regioselective chemical modification of monoclonal antibodies Regioselective chemical modification of monoclonal antibodies

1990-11-14

1993-05-04

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

5303881, 5303911, 5303913, 5303915, 5303917, 5303919, 424 9, 424 8591, 435 71, 436512, A61K 4902, C07K 1528, C07K 1502

Patent

active

052080080

ABSTRACT:
A method of selectively modifying an immunoglobulin having at least one Fab region and at least one Fc region, each region having an isoelectric point wherein said isoelectric point of the Fab fragment of said immunoglobulin is different than the isoelectric point of the Fc fragment of the immunoglobulin, said method comprising modification of the immunoglobulin at a pH between the respective isoelectric points of the Fab and Fc fragments of the immunoglobulin.

REFERENCES:
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Ahmad et al. (1988) Trends in Biotech. 6:246-251.
Blair et al. (1983) J. Immunol. Methods 59:129-143.
Dictionary of Immunology, W. Herbert et al., eds., Blackwell Scientific Publications 1985, Oxford, pp. 80-81.
Ghose et al. (1983) Methods Enzymol. 93:280-333.
Simonson et al. (1988) Clin. Chem. 34/9:1713-1716.

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