Regioselective and stereoselective oxidation of fused ring...

Details Regioselective and stereoselective oxidation of fused ring... Regioselective and stereoselective oxidation of fused ring...

2005-03-21

2010-06-01

Badio, Barbara P (Department: 1628)

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

Reexamination Certificate

active

07728157

ABSTRACT:
An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective sulfonation of a fused ring system. The fused ring system base can be, for example, a steroid ring base. The aminosterol compounds are effective as, among others, antibiotics, antiangiogenic agents and NHE3 inhibitors.

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