Regime for paclitaxel in Kaposi's sarcoma patients

Details Regime for paclitaxel in Kaposi's sarcoma patients Regime for paclitaxel in Kaposi's sarcoma patients

1996-11-08

1998-05-26

Knode, Marian C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514450, 514451, 514452, 514359, 514383, 514 8, A01N 4302, A01N 4332, A01N 4364, A61K 3800

Patent

active

057565376

ABSTRACT:
This invention provides for novel dose regimen of paclitaxel to treat Kaposi's sarcoma. Unlike current paclitaxel therapy protocols, the claimed dosages are lower yet surprisingly as effective in regression of KS tumors. In addition, the lower doses are accompanied with fewer incidents of undesired side effects. The effectiveness of low doses of paclitaxel as well as fewer and less debilitating side effects, makes this therapy protocol the first that can be used for long term and as maintenance therapy in the management of patients with Kaposi's sarcoma.

REFERENCES:
patent: 5565478 (1996-10-01), Kohn et al.
Straubinger et al. JNCI 15:69-78, (1993).
Gianni, et al., J Clin. Oncol., 13(1):180-90 (1995).
Saville, et al., Blood, 84(10 Suppl 1):S103, Abstract 163 (1994).
Wiernak, et al., J. Clin. Oncol., 5:1232-9 (1987).
Huizing, et al., J Clin. Oncol.11(11):2127-2135 (1993).
Eisenhauer et al., J Clin. Oncol. 12: 2654-2666 (1994).
McGuire, et al. Ann. Int. Med., 111:273-279 (1989).
Holmes, et al. J. Natl. Cancer Inst., 83:1797-1805 (1991).
Kohn et al., J. Natl. Cancer Inst., 86:18-24 (1994).
Kohn, et al., American Society for Clinical Oncology, 12, Abstract 814 (1993).
Donehower, et al., Cancer Treatment Reports 71(12):1171-7 (1987).
Brown, et al., J Clin. Oncol., 9(7):1261-7 (1991).
Saville, et al., Lancet 346(8966):26-8 (1995).

Affiliated with

Also associated with

Rating

Regime for paclitaxel in Kaposi's sarcoma patients does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Regime for paclitaxel in Kaposi's sarcoma patients, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Regime for paclitaxel in Kaposi's sarcoma patients will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1960733