Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Hormone or other secreted growth regulatory factor,...
Patent
1995-02-28
1999-03-23
Feisee, Lila
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Hormone or other secreted growth regulatory factor,...
514 12, 514 21, 530350, A61K 3816, C07K 1452
Patent
active
058855840
ABSTRACT:
The invention concerns a process for improving the regeneration of oligodendrocytes, in particular of human oligodendrocytes, in which oligodendrocytes are treated in cell culture with nerve growth factor (NGF) or active fragments of NGF. Furthermore a composition is disclosed for treating diseases in which a demyelination of nerve fibres occurs which contains NGF or an active fragment thereof as the active substance, if desired, together with the usual pharmaceutical vehicles, auxiliary substances, fillers and diluents.
REFERENCES:
patent: 5082774 (1992-01-01), Heinrich
patent: 5210185 (1993-05-01), Della Valle et al.
Brocke S. et al. 1994. In: "Autoimmune disease models, a guidebook", eds by ohen, IR. et al. Academic Press, N.Y. pp. 1-14.
Louis, J.C. et al. 1993. Science 259:689-692.
Miller, D.J. et al. 1996. Brain Pathology 6:331-344.
Scolding, N.J. et al. 1995. Neuroscience Letters, 183:75-78.
Cirelli, R. et al. 1995. Clinical Immunotherapeutics, 3:27-87.
Dsouza, S.D. et al. 1996. J. Neuroscience Research, 43:289-298.
Hird, V. et al. 1990. In. Genes and Cancer, Carney D (eds). John Wiley & Son.
Koliatsos et al. 1990 J. Neuro Science, 10:3801-3813.
Mercanti et al. 1977. Biochim. Biophys. Acta 496:412-419.
Poster Abstract: Althaus et al., Proceedings of the 19th Gottingen Neurobiology Conference, "Influence of Growth Factors on Proliferation and Process Regeneration of Cultured Mature Oligondendrocytes", May, 1991. Published in Synapse Transmission Modulation, Proceedings of the 19th Gottingen Neurobioloby Conference (N. Elsmer et al., eds), George Thieme Vertag Stuttgart, New York.
"Porcine Model for Studying the Passage of Non-Depolarizing Neuromuscular Blockers Through the Blood-Brain Barrier", Werba A. et al., British Journal of Anaesthesia (1992) 69: 382-386.
"Observations on Remyelination in the Rabbit Spinal Cord Following Domyelination Induced By Lysolecithin", Blakemore, WF, Neuropath. and Appl. Neurobio. (1978), 4, 47-59.
"Genetic Factors in Altherosclerosis: Approaches and Model Systems", Monographs in Human Genetics, vol. 12 (1989).
"The Yucatan Miniature Pig and Minimum Stress Methodology in the Laboratory", Panepinto, LM et al., 8th ICLAS/CALS Symp., Vancouver 1983.
"Development of a Piglet Model of Status Epilepticus: Preliminary Results", Terndrup, TE et al., Laboratory Investigation, Feb. 1993.
"Epithelial Wound Healing Enhanced by Transforming Growth Factor-.alpha. and Vaccinia Growth Factor", Schultz, TS et al., Science, vol. 235, pp. 350-352.
"Nerve-growth factor induced proliferation and enhances fiber regeneration in oligodendrocytes isolated from adult pig brain", Neurosci. Letters, 135, (1992) pp. 219-223.
"Interferon beta-1b is effective in relapsing-remitting multiple sclerosis" Paty, DW et al., Neurology, Apr. 1993, pp. 662-667.
"Growth regulation of skin cells by epidermal cell-derived factors: application for wound healing", Eisinger, et al., Natl. Acad. Sci., USA, pp. 1937-1941, Mar. 1988.
"Isolation of Human Nerve Growth Factor From Placental Tissue", Goldstein et al., Neurochemical Research (3), pp. 175-183, 1978.
Halbrook et al., "Production and Characterization of Biologically Active Recombinant Beta Nerve Growth Factor", Mol. & Cell. Biology, Jan. 1988, pp. 452-456.
Calbiochem-Catalogue (1990-1991), p. 21, Catalogue #616398.
Schroter et al., "The Phorbolester TPA Dramatically Accelerates Oligodendroglial Process Regeneration", Naturwissenschaften 74, pp. 393-394 (1987).
Hama et al., "Protein kinase C as a component of a nerve growth factor-sensitive phosphorylation system in PC12 cells", Proc. Natl. Acad. Sci., vol., 83, pp. 2353-2357, Apr. 1986.
Althaus et al., "Nerve growth factor induces proliferation and enhances fiber regeneration in oligodendrocytes isolated from adult pig brain", Neuroscience Letters, 135 (1992), pp. 219-223.
Althaus, et al., "Protein Kinase C Stimulation Enhances the Process Formation of Adult Oligodendrocytes and Induces Proliferation", Journal of Neuroscience Research, vol. 29, pp. 481-489, Aug. 1991.
Hall et al., "Suppression of Nerve Growth Factor-directed Neurite Outgrowth in PC12 Cells by Sphingosine, and Inhibitor of Protein Kinase C*", The Journal of Biological Chemistry, vol. 263, No. 9, May 1987, pp. 4460-4466.
Althaus et al., "Protein Kinases A And C Are Involved In Oligodendroglia Process Formation", Nato Asi Series, vol. H 43, Cellular and Molecular Biology of Myelination, pp. 248-253, 1989.
Hunter et al., O-2A Glial Progenitors From Mature Brain Respond to CNS Neural Cell Line-Derived Growth Factors, Journal of Neuroscience Research, vol. 28, pp. 574-582, 1991.
Althaus et al., "Isolation and Cultivation of Mature Oligodendroglial Cells", Naturwissenschaften 71, pp. 309-315, 1984.
Lillien et al., "Nerve growth factor is a mitogen for cultured chromaffin cells", Letters to Nature, vol. 317, Oct. 1985, pp. 632-634.
Gebicke-Harter et al., "Bulk Separation and Long-Term Culture of Oligodendrocytes from Adult Pig Brain. I Morphological Studies", Journal of Neurochemistry, New York, 1984, pp. 257-368.
Althaus Hans-Hinrich
Bartke Ilse
Unger Jurgen
Bansal Geetha P.
Boehringer Mannheim GmbH
Feisee Lila
Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
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