Regeneration of kidney tissue and use of autocrine growth factor

Details Regeneration of kidney tissue and use of autocrine growth factor Regeneration of kidney tissue and use of autocrine growth factor

1995-12-15

1998-10-13

Carlson, Karen C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530399, C07K 14475

Patent

active

058212183

ABSTRACT:
Autocrine growth factors and isoforms of those factors have been identified, isolated, purified and manipulated. Nucleic acid segments coding for the factors, and antibodies directed to the factors are also aspects of the present invention. The effect of these growth factors on cells is to enhance their growth by increasing mitogenesis. In particular, the growth factors stimulate kidney epithelial cell growth. The growth factors differ from others previously reported in their molecular weights and other properties, for example, resistance to denaturation by dithiothreitol. Methods of preparation and use of the factors are also described. The growth factors are released from kidney epithelial cells by short exposures to a low-sodium environment. The factors have potential for treatment of kidney disease.

REFERENCES:
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Holley et al., Proc. Natl. Acad. Sci., 77(10):5989-5992, 1980.
Toback, Kidney International, 12:193-198, 1977.
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