Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;... – Enzyme or microbial cell is immobilized on or in an...
Patent
1988-09-19
1990-06-12
Naff, David M.
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
Enzyme or microbial cell is immobilized on or in an...
435179, 436524, 436530, 530811, 530814, 536 63, 536 69, 536 84, 536 99, C12N 1114, C12N 1112, G01N 33548, C07K 1712
Patent
active
049332848
ABSTRACT:
A regenerable support matrix useful for immobilization of biologically active materials is prepared by coating a core support with a cellulose ester, removing ester groups by hydrolysis to produce hydroxyl groups and converting the hydroxyl groups to dialkylaminoalkyl ether groups. The support matrix can immobilize biologically active proteinaceous materials with a net negative charge by adsorption. The support matrix is readily regenerated when an immobilized biologically active material becomes inactive by washing the support with a base or salt solution and adsorbing additional biologically active material to the support. Multiple cycles of immobilization and regeneration are possible without significant deleterious affects.
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Kirk-Othmer, "Encyclopedia of Chemical Technology", Third Ed., vol. 9, pp. 155-157.
Lapins Chris D.
Tsuda Yoshihisa
McBride Thomas K.
Naff David M.
Snyder Eugene I.
UOP
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