Refunctionalized oxyfluorinated surfaces

Details Refunctionalized oxyfluorinated surfaces Refunctionalized oxyfluorinated surfaces

1994-09-16

1997-05-06

Achutamurthy, Ponnathapura

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is inorganic

436518, 436528, 436531, 427535, 427569, 427 78, 427 96, 427 99, 427255, 427304, 428615, 428618, 428620, 428412, 428421, 4284231, 4284246, 428426, 428429, 428457, 428480, 428500, 428523, G01N 33543, H05H 100, B05D 500, B32B 2700

Patent

active

056270798

ABSTRACT:
Permanently substituted oxyfluorinated surfaces can be formed on non-fluorinated substrates having a fluorinated surface or fluorocarbon coating applied by gas phase surface fluorination or plasma deposition. The oxyfluorinated surfaces can be refunctionalized by bonding organosilanes, isothiocyanate-containing fluorescent compounds and proteins, such as enzymes, antibodies and peptides directly to such surfaces. Surfaces refunctionalized with such protein based groups are useful in the fabrication of biological sensors, devices for separation of cell lines, filtration applications for selective binding of antigens. Masking techniques can be employed in forming a predetermined pattern of covered and exposed surfaces, for example, prior to oxyfluorination.

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Y. Haque et al, J. Appl. Polymer Sci., vol. 32, pp. 4369-4381, 1986.
F. V. Bright et al, Anal. Chim. Acta, vol. 262, pp. 323-330, 1992.

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