Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-06-06
1998-05-26
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530418, 530419, 530420, 530422, 530423, 530424, 435 691, 4351723, 4353201, 4352523, C07K 14475, A61K 3822
Patent
active
057566720
ABSTRACT:
A composition is provided comprising about 0.1 to 15 mg/mL of a polypeptide in a buffer having a pH of about 7-12 comprising about 5-40% (v/v) of an alcoholic or polar aprotic solvent, about 0.2 to 3M of an alkaline earth, alkali metal, or ammonium salt, about 0.1 to 9M of a chaotropic agent, and about 0.01 to 15 .mu.M of a copper or manganese salt. The buffer is suitably used in a method for refolding improperly folded polypeptides.
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Builder Stuart
Hart Roger
Lester Philip
Reifsnyder David
Genentech Inc.
Hasak Janet E.
Mertz Prema
Ulm John
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