Reference control for cell by cell analysis

Details Reference control for cell by cell analysis Reference control for cell by cell analysis

2011-06-28

2011-06-28

Gitomer, Ralph (Department: 1657)

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

C436S010000, C436S017000

Reexamination Certificate

active

07968279

ABSTRACT:
A reference control for cell by cell analysis on flow cytometric analyzers contains cellular analogs made of permeated blood cells containing therein aggregated intracellular proteins and preserved antigenic sites thereof, having cellular membrane permeable to antibodies and a suspension medium. The reference control is frozen after being prepared and thawed prior to use. The cellular analogs further contain a fluorescence marker therein. Further disclosed are a method of making the reference control and a method using the reference control, as an internal or stand-alone control, for measurements of cellular hemoglobin and cellular hemoglobin variant of a blood sample.

REFERENCES:
patent: 4777139 (1988-10-01), Wong et al.
patent: 5422277 (1995-06-01), Connelly et al.
patent: 5478722 (1995-12-01), Caldwell
patent: 5677145 (1997-10-01), Ryan
patent: 7176031 (2007-02-01), Li et al.
patent: 7361513 (2008-04-01), Ryan et al.
patent: 7541190 (2009-06-01), Van Agthoven et al.
patent: 7678578 (2010-03-01), Van Agthoven et al.
patent: 2003/0118637 (2003-06-01), Jordan et al.
patent: 2004/0214243 (2004-10-01), Burshteyn et al.
patent: 2006/0178294 (2006-08-01), Van Agthoven et al.
patent: 2007/0020612 (2007-01-01), Van Agthoven et al.
patent: 2007/0269460 (2007-11-01), Inchauspe et al.
Campbell et al “Detection of Hemoglobin Variants in Erythrocytes by Flow Cytometry”, Cytometry 35:242-248 (1999).
Goldstein et al “Glycated Hemoglobin: Methodologies and Clinical Applications”, Clin Chem 32/10(B), B64-B70 (1986).
Sacks, David B. “Global Harmonization of Hemoglobin A1c”, Clin Chem 51, No. 4, pp. 681-683 (2005).

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