Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1995-03-15
1996-04-16
Ford, John M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C07D40106
Patent
active
055084044
ABSTRACT:
A process of reductive amination efficiently yields an HIV protease inhibitor.
REFERENCES:
Abdel-Magid, et al., "Reductive Amination of Aldehydes and Ketones by Using Sodium Triacetoxyborohydride", Tet. Letters, vol. 31, No. 329, pp. 5595-5598, 1990.
Borch, et al., "The Cyanohydridoborate Anion as a Selective Reducing Agent", J. Am. Chem Soc., vol. 93.12, pp. 2897-2904, 1971.
March, "The Addition of Alcohols to Aldehydes and Ketones", Advanced Organic Chemistry (Third Edition), pp. 798-800, 1985.
Askin David
Cianciosi Steven J.
Hoerrner Robert S.
Ford John M.
Merck & Co. , Inc.
Meredith Roy D.
Tribble Jack L.
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