Reductive amination of an amino acid or of an amino acid derivat

Details Reductive amination of an amino acid or of an amino acid derivat Reductive amination of an amino acid or of an amino acid derivat

1992-07-13

1995-02-07

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560 24, 560 38, 560159, 560171, C07D20716

Patent

active

053876962

ABSTRACT:
N-substituted .alpha.-amino acids and dipeptides are valuable intermediate products for the production of inhibitors of the angiotensin converting enzyme (ACE); representatives are e.g. enalapril and ramipril. These compounds are prepared by means of hydrogenolytic conversion of a primary amine with a ketone with the addition of an organic or inorganic base; among the inorganic bases, basic aluminum oxide is preferred. The use of chiral organic bases favors the production of a diastereomer.

REFERENCES:
patent: 4474692 (1984-10-01), Oka et al.
Article entitled "Synthesis and Pharmacology of the Potent Angiotensin-Converting . . . " J. Med. Chem. (1985) 28, 1596-1602, American Chemical Society; Johnson, et al.
Chemistry Letters, pp. 1691-1694, (1988) The chemical society of Japan; Iwasaki et al.

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