Reductive alkylation process to prepare tertiary aminoaryl compo

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

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544402, 544403, 546143, 564395, 564396, 564398, 564218, 564 95, 564415, C07C20926, C07C20924

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058615350

ABSTRACT:
Tertiary aminoaryl compounds, such as N,N'dialkylaminoaryl compounds, are prepared using successive reductive steps without isolation therebetween, at high temperature and pressure. A nitroaryl compound is reduced using a ketone as both solvent and reactant in a reductive environment, and the resulting intermediate is further reacted with an aldehyde in the same reaction mixture without isolation to provide the second substituent on the amino group.

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Catalysis of Organic Reactions, Kosak, Dekker, Inc. 1984.

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