Reductive alkylation of secondary amines with hydrosilane

Details Reductive alkylation of secondary amines with hydrosilane Reductive alkylation of secondary amines with hydrosilane

2000-01-10

2000-08-08

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

546446, 546473, 546397, C07C20928, C07D24314, C07D23364, C07D33364

Patent

active

061003956

ABSTRACT:
A novel process for the production of tertiary amines by reductive alkylation of second amine using hydrosilane and a Lewis acid is disclosed. The novel process has applications in the preparation of imidazole-containing benzodiazepines, inhibitors of farnesyl protein transferase.

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