Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Chemical aftertreatment – e.g. – acylation – methylation – etc.
Patent
1997-11-12
1999-09-14
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Chemical aftertreatment, e.g., acylation, methylation, etc.
530317, 530322, 530333, 514 9, A61K 3800, C07K 512
Patent
active
059524669
ABSTRACT:
This invention is concerned with improved processes for reductive alkylation of glycopeptide antibiotics. The improvement residing in providing a source of copper which results in the initial production of a copper complex of the glycopeptide antibiotic. Reductive alkylation of this complex favors regioselective alkylation and increased yields. Copper complexes of the glycopeptide antibiotic starting materials and of the alkylated products are also part of the invention.
REFERENCES:
patent: 4568490 (1986-02-01), Umezawa et al.
patent: 4698327 (1987-10-01), Nagarajan et al.
patent: 5312738 (1994-05-01), Hamill et al.
Nagabhushan et al., Carbohydrate Research, vol. 130, pp. 243-249, 1984.
Cooper et al., The Journal of Antibiotics, vol. 49, No. 6, pp. 575-587, 1996.
Wong et al., Analytical Biochemistry, vol. 139, pp. 58-67, 1984.
Nagarjan et al., The Journal of Antibiotics, vol. 42, No. 1, pp. 63-72, 1988.
Lee et al., Biochemistry, vol. 28, pp. 1856-1861, 1989.
Popiernek et al, J. Am. Chem. Soc., vol. 113, pp. 2264-2270, 1991.
Fultz et al., Electrocanalysis, vol. 3, No. 6, pp. 519-526, 1991.
Tsuchiya, T., et al., Tetrahedron Letters, 51, 4951-4954 (1979).
Hanessian, S., et al., Tetrahedron Letters, 12, 1031-1034 (1978).
Hanessian, S., et al., Tetrahedron Letters, 12, 1035-1038 (1978).
Abstracts of Papers, 210th ACS National Meeting, American Chemical Society, Chicago, Illinois, (Aug. 1995).
Berglund Richard Alan
Lockwood Nancy Anne
Magadanz Howard Eugene
Zheng Hua
Eli Lilly and Company
Mohamed Abdel A.
Musser Arlene K.
Tsang Cecilia J.
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