Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Chemical aftertreatment – e.g. – acylation – methylation – etc.
Patent
1999-04-12
1999-12-07
Woodward, Michael P.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Chemical aftertreatment, e.g., acylation, methylation, etc.
530317, 530322, 530333, 514 9, A61K 3800, A61K 3814, C07K 512
Patent
active
05998581&
ABSTRACT:
This invention is concerned with improved processes for reductive alkylation of glycopeptide antibiotics. The improvement residing in providing a source of copper which results in the initial production of a copper complex of the glycopeptide antibiotic. Reductive alkylation of this complex favors regioselective alkylation and increased yields. Copper complexes of the glycopeptide antibiotic starting materials and of the alkylated products are also part of the invention.
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Berglund Richard Alan
Lockwood Nancy Anne
Magadanz Howard Eugene
Zheng Hua
Eli Lilly and Company
Mohamed Abdel A.
Musser Arlene K.
Woodward Michael P.
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