Reduction products of rapamycin

Details Reduction products of rapamycin Reduction products of rapamycin

1991-05-07

1992-04-07

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514321, 540456, A61K 31395, C01D49100

Patent

active

051028760

ABSTRACT:
Reduction of rapamycin with DIBAL furnishes either the 15-hydroxyrapamycin or 15,27-bis(hydroxy)rapamycin, depending upon the reaction conditions, having the general structure ##STR1## where Y is --CO-- --CH(OH)--. The compounds of this invention are useful in treating transplant rejection, host vs. graft disease, autoimmune diseases, diseases of inflammation, and fungal infections.

REFERENCES:
patent: 3929992 (1975-12-01), Seghal et al.
patent: 3993749 (1976-11-01), Seghal et al.
patent: 4316885 (1982-02-01), Rakhit
patent: 4401653 (1983-04-01), Eng
patent: 4650803 (1987-03-01), Stella et al.
patent: 4885171 (1989-12-01), Surendra et al.
J. Antibiot. 28, 721-732, (1975).
J. Antibiot. 31, 539-545 (1978).
FASEB 3, 3411, 5256 (1989).
Lancet, pp. 1183-1185 (1978).
J. Am. Chem. Soc. 103, pp. 3215-3217 (1981).
Immunology, C. V. Moseby Co., pp. 12.8-12.11 (1989).

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