Reduction process for the preparation of 4-unsubstituted azetidi

Details Reduction process for the preparation of 4-unsubstituted azetidi Reduction process for the preparation of 4-unsubstituted azetidi

1984-10-30

1987-07-28

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540363, 540357, C07D20508, C07B 4108

Patent

active

046833030

ABSTRACT:
Novel process for the preparation of azetidin-2-ones of the formula ##STR1## wherein R.sup.1 and R.sup.2 independently from each other are hydrogen, or an organic group linked to the ring carbon via a carbon atom, a nitrogen atom or an oxygen atom, characterized in that a corresponding 4-acyloxyazetidin-2-one, which is substituted by a group --O--CO--R.sup.3 at the 4-position, wherein R.sup.3 is hydrogen or an organic radical stable at the reaction conditions, is reacted with a complex metal hydride comprising reactive hydride ions, such as, lithium borohydride, sodium borohydride, potassium borohydride, zinc borohydride or tetraorganoammonium borohydride.

REFERENCES:
Brown et al., Tetrahedron 35, 567, (1979).
Rompps Chemie--Lexikon, Franckh'sche Verlagshandlung (Stuttgart), 8th Ed., p. 7.
Angewandte Chemie, vol. 74, p. 523, Lactame, Polymerisation und Verwendung Als Faserrohstoffe; Aug. 7, 1962; Graf, Lohaus et al.
Liebig's Ann. Chemie, vol. 614, (1968), p. 158, by Testa, Fontanella, et al.
Holley, J.A.C.S. 71, 2129, June 1949.
Allan and Morgan, "Action of Mesitylmagnesium Bromide etc.", Chemistry & Industry, Jul. 19, 1975, p. 614.
Suarato, Lombardi, et al., Tetrahedron Letters, 1978, p. 4059.
Birkofer, Schramm; Ann. Chem., 1975, 2195.
Searles & Wann; Chem & Industry, 1964, p. 2097., 12/19/64.
Testa, Fontanella et al; Helv. Chim. Acta 42, 2370.
Testa, Fontanella et al.; Disubstituierte Azetidine Ann. Chem. 626, 114, (1959).

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