Reduction process for cephalosporin sulfoxides

Details Reduction process for cephalosporin sulfoxides Reduction process for cephalosporin sulfoxides

1976-06-09

1977-08-23

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424246, 544 21, 544 24, 544 25, 544 26, 544 27, 544 28, 544 29, 544 30, 544 22, C07D50104

Patent

active

040440028

ABSTRACT:
Cephalosporin sulfoxides are reduced to the corresponding cephalosporin with acyl bromides, e.g., acetyl bromide, in the presence of a bromine scavenger, e.g., an olefin, acetylene, phenol, phenol ether, or an organophosphite. For example, p-nitrobenzyl 7-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate sulfoxide is reduced with acetyl bromide in the presence of amylene to p-nitrobenzyl 7-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate.

REFERENCES:
patent: 3641014 (1972-02-01), Murphy et al.

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