Reduction of the severity 3'-azido-3'-deoxythymidine-induced ane

Details Reduction of the severity 3'-azido-3'-deoxythymidine-induced ane Reduction of the severity 3'-azido-3'-deoxythymidine-induced ane

1988-02-22

1989-10-17

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

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Taste or smell or chemical irritation to the eye, nose, or...

514 50, 514274, 514814, 514922, A61K 3170, A61K 31505

Patent

active

048746029

ABSTRACT:
A method of reducing anemia caused by the administration of 3'-azido-3'-deoxythymidine to an animal which comprises treating said animal with a compound which inhibits the enzyme uridine phosphorylase in order to increase cellular uridine levels is disclosed. A particularly-effective compound is 5-benzylacyclouridine.

REFERENCES:
Niedzwicki et al., Biochem. Pharmacol., 31:1857-1861, (1982).
Chu et al., Cancer Res., 44:1852-1856, (1984).

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