Reduction of the hook effect in membrane-based assay devices

Details Reduction of the hook effect in membrane-based assay devices Reduction of the hook effect in membrane-based assay devices

2007-07-20

2010-02-16

Nguyen, Bao-Thuy L (Department: 1641)

Chemistry: analytical and immunological testing

Involving diffusion or migration of antigen or antibody

C435S007100, C435S007920, C435S288600, C435S287100, C436S518000, C436S523000, C436S805000, C436S809000, C422S051000, C422S051000, C422S051000, C422S051000, C422S067000

Reexamination Certificate

active

07662643

ABSTRACT:
A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a chromatographic zone on which is disposed a plurality of microporous particles. The chromatographic zone can effectively reduce the “hook effect” in a simple, efficient, and relatively inexpensive manner. In particular, the plurality of microporous particles allows larger-sized analyte/probe complexes to reach the detection zone before the uncomplexed analyte. Because the uncomplexed analyte is substantially inhibited from competing with the complexes for the binding sites at the detection zone, the incidence of “false negatives” may be limited, even at relatively high analyte concentrations.

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