Reduction of the electrocardiographic QT interval

Details Reduction of the electrocardiographic QT interval Reduction of the electrocardiographic QT interval

2007-05-08

2007-05-08

Chism, B. Dell (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600

Reexamination Certificate

active

10380301

ABSTRACT:
The present invention relates to the use of proinsulin C-peptide or a variant, derivative or fragment thereof in the manufacture of a medicament for reducing the OTc interval and the use of proinsulin C-peptide or a variant, derivative or fragment thereof in the manufacture of a medicament for reducing the risk of sudden death or ‘dead in bed’ syndrome; particularly in patients suffering from IDDM.

REFERENCES:
patent: 6610649 (2003-08-01), Wahren et al.
patent: WO 98/13384 (1998-04-01), None
patent: WO 9813384 (1998-04-01), None
patent: WO 02/36129 (2002-05-01), None
Sawicki et al., Diabetologia 1996, vol. 39, pp. 77-81.
Ido et al., 1997, Science vol. 277, pp. 563-566.
Sovik, et al., Diabetes Care, 1999, vol. 22, Suppl. 2, B40-42.
Wahren, et al., “Role of C-Peptide In Human Physiology”,Am. J. Physiol. Endocrinol. Metab., 278(5):E759-E768 (2000).
Bellavere, et al., Diabetes, Abstract only, 41(5):633-640 (1992).
Cameron, et al. ,Diabetes, Abstract only, 46(Suppl. 2):S31-S37 (1997).
Cotter, et al.,ADA Meeting in Philadelphia, Abstract only, (2001).
Davey, P.,Eur. J. Heart Fail., Abstract only, 2(3):265-271 (2000).
Ewing, et al.,Diabetologia, Abstract only, 34(3):182-185 (1991).
Ewing, et al.,Diabetic Med., Abstract only, 7(1):23-26 (1990).
Forst, et al.,Diabetes, Abstract only, 48;A201 (1999).
Forst, et al.,J. Clin. Invest., 101(10):2036-2041 (1998).
Galetta, et al.,G. Ital. Cardiol., Abstract only, 29(6):675-678 (1999).
Gastaldelli, et al.,Am. J. Physiol. Regul. Integr. Comp. Physiol., Abstract only, 279(6):R2022-R2025 (2000).
Hansen, et al.,Supplementum 2 für Kardiologie, Abstract only, Band 90, 1023 (2001).
Hansen, et al.,EASD Meeting in Glasgow, Abstract only, (2001).
Jermendy, et al.,Acta Cardiol., Abstract only, 46(2):189-200 (1991).
Johansson, et al.,Diabetic Med., 17:1-9 (2000).
Johansson, et al.,Diabetologia, 39:687-695 (1996).
Johansson, et al.,Diabetologia, 35:1151-1158 (1992).
Johansson, et al.,J. Clin. Endocrinol. Metabol., 77(4):976-981 (1993).
Kahn, et al.,J. Clin. Endocrinol. Metab., Abstract only, 64(4):751-754 (1987).
Katsuoka, et al.,Clin. Auton. Res., Abstract only, 8(3):139-143 (1998).
Lengyel, et al.,Orv. Hetil., Abstract only, 138(6):337-341 (1997).
Lindström, et al.,Acta Physiol. Scand., 156:19-25 (1996).
Lo, et al.,Am. J. Cardiol., Abstract only, 72(3):305-309 (1993).
Maffi, et al.,Diabetes, Abstract only, 48:A55 (1999).
Meyer, et al.,Transplantation, 66(2):233-240 (1998).
Miyamoto, et al.,Jpn. J. Pharmacol., Abstract only, 86(1):114-119 (2001).
Ohtomo, et al.,Diabetologia, 39:199-205 (1996).
Oka, et al.,Diabetes Res. Clin. Pract., Abstract only, 31(1-3):63-70 (1996).
Pitkänen, et al.,Diabetes, 47:248-254 (1998).
Rigler, et al.,PNAS, 96(23):13318-13323 (1999).
Rossing, et al.,Diabetic Med., Abstract only, 18(23):199-205 (2001).
Sagie, et al.,Am. J. Cardiol., Abstract only, 70(7):797-801 (1992).
Sawicki, et al.,Diabetologia, 39(1):77-81 (1996).
Sivieri, et al.,Diabetic Med., Abstract only, 10(10):920-924 (1993).
Tattersall, et al.Diabetic Med., 8:49-58 (1991).
Tentolouris, et al.,Eur. J. Clin. Invest., Abstract only, 27(12):1049-1054 (1997).
Veglio, et al.,Diabetic Med., Abstract only, 12(4):302-306 (1995).
Veglio, et al.,Diabetic Care, Abstract only, 23(9):1381-1383 (2000).
Weston, et al.,Diabetic Medicine, 16:626-631 (1999).
Weston, et al.,Heart, Abstract only, 78(1):56-60 (1997).
Ahnve et al., “Prognostic importance of QTcinterval at discharge after acute myocardial infarction: a multicenter study of 865 patients”,Am. Hear J., 108(2):395-400 (1984).

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