Reduction of skin irritation and resistance during electrotransp

Details Reduction of skin irritation and resistance during electrotransp Reduction of skin irritation and resistance during electrotransp

1995-04-24

1997-04-29

Bockelman, Mark

Surgery

Means for introducing or removing material from body for...

Treating material applied to or removed from external...

604 20, A61N 130

Patent

active

056244150

ABSTRACT:
An electrotransport delivery device utilizing reservoir buffering at a select pH ranges in order to reduce skin irritation and skin resistance is provided. Cathodic reservoirs are buffered to a pH of less than about 4, preferably to a pH in the range of about 2 to 4, while anodic reservoirs are buffered to a pH above about 4, preferably to a pH in the range of about 4 to 10. Another electrotransport delivery device utilizes a potassium sensor to monitor potassium efflux from the skin. Potassium efflux above a certain predetermined level has been found to be a precursor to skin irritation/erythema. Operation of the device is modified (eg, terminated) when the predetermined potassium efflux level is sensed.

REFERENCES:
patent: 4842577 (1989-06-01), Konno et al.
patent: 4915685 (1990-04-01), Petelenz et al.
patent: 5036861 (1991-08-01), Sembrowich et al.
patent: 5125894 (1992-06-01), Phipps et al.
patent: 5279543 (1994-01-01), Glikfeld et al.

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